Seroatlas · Human Serome Atlas

CDIP1

Cell death-inducing p53-target protein 1

Also known as: C16orf5, CDIP, CDIP1_HUMAN, LITAFL

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H305
Gene: CDIP1
Ensembl: ENSG00000089486
Chromosome: 16
Canonical length: 208 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Centrosome

OverviewNCBI Gene

Predicted to enable zinc ion binding activity. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator. Located in cytoplasmic side of late endosome membrane; cytoplasmic side of lysosomal membrane; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

208 residues, UniProt reviewed canonical sequence.

>Q9H305|CDIP1
     1  MSSEPPPPYP GGPTAPLLEE KSGAPPTPGR SSPAVMQPPP GMPLPPADIG PPPYEPPGHP
    61  MPQPGFIPPH MSADGTYMPP GFYPPPGPHP PMGYYPPGPY TPGPYPGPGG HTATVLVPSG
   121  AATTVTVLQG EIFEGAPVQT VCPHCQQAIT TKISYEIGLM NFVLGFFCCF MGCDLGCCLI
   181  PCLINDFKDV THTCPSCKAY IYTYKRLC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDIP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.63
Highest tissue expression: 160 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 160 nTPM
basal ganglia: 129 nTPM
cerebellum: 116 nTPM
amygdala: 113 nTPM
hypothalamus: 112 nTPM
hippocampal formation: 106 nTPM

Single-cell type

astrocytes: 48 nCPM
other brain neurons: 45 nCPM
brain excitatory neurons: 38 nCPM
brain inhibitory neurons: 38 nCPM
choroid plexus epithelial cells: 34 nCPM
bergmann glia: 34 nCPM

Immune cell

non-classical monocyte: 18 nTPM
eosinophil: 15 nTPM
NK-cell: 12 nTPM
gdT-cell: 12 nTPM
intermediate monocyte: 9 nTPM
naive CD4 T-cell: 9 nTPM

Brain region

cerebral cortex: 162 nTPM
white matter: 124 nTPM
thalamus: 114 nTPM
basal ganglia: 112 nTPM
amygdala: 109 nTPM
pons: 107 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.45
gnomAD pLI: 0.87
gnomAD missense Z: 0.44
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

Molecular functions

zinc ion binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDIP1 as an antibody target. Whether an autoantibody or antibody against CDIP1 could matter depends on whether native CDIP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDIP1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDIP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...