Seroatlas · Human Serome Atlas

CDHR3

Cadherin-related family member 3

Also known as: CDH28, CDHR3_HUMAN, FLJ23834, FLJ44366

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZTQ4
Gene: CDHR3
Ensembl: ENSG00000128536
Chromosome: 7
Canonical length: 885 aa
Protein class: Disease related genes, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable beta-catenin binding activity and cadherin binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell adhesion mediated by cadherin; and cell-cell junction organization. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

885 residues, UniProt reviewed canonical sequence.

>Q6ZTQ4|CDHR3
     1  MQEAIILLAL LGAMSGGEAL HLILLPATGN VAENSPPGTS VHKFSVKLSA SLSPVIPGFP
    61  QIVNSNPLTE AFRVNWLSGT YFEVVTTGME QLDFETGPNI FDLQIYVKDE VGVTDLQVLT
   121  VQVTDVNEPP QFQGNLAEGL HLYIVERANP GFIYQVEAFD PEDTSRNIPL SYFLISPPKS
   181  FRMSANGTLF STTELDFEAG HRSFHLIVEV RDSGGLKAST ELQVNIVNLN DEVPRFTSPT
   241  RVYTVLEELS PGTIVANITA EDPDDEGFPS HLLYSITTVS KYFMINQLTG TIQVAQRIDR
   301  DAGELRQNPT ISLEVLVKDR PYGGQENRIQ ITFIVEDVND NPATCQKFTF SIMVPERTAK
   361  GTLLLDLNKF CFDDDSEAPN NRFNFTMPSG VGSGSRFLQD PAGSGKIVLI GDLDYENPSN
   421  LAAGNKYTVI IQVQDVAPPY YKNNVYVYIL TSPENEFPLI FDRPSYVFDV SERRPARTRV
   481  GQVRATDKDL PQSSLLYSIS TGGASLQYPN VFWINPKTGE LQLVTKVDCE TTPIYILRIQ
   541  ATNNEDTSSV TVTVNILEEN DEKPICTPNS YFLALPVDLK VGTNIQNFKL TCTDLDSSPR
   601  SFRYSIGPGN VNNHFTFSPN AGSNVTRLLL TSRFDYAGGF DKIWDYKLLV YVTDDNLMSD
   661  RKKAEALVET GTVTLSIKVI PHPTTIITTT PRPRVTYQVL RKNVYSPSAW YVPFVITLGS
   721  ILLLGLLVYL VVLLAKAIHR HCPCKTGKNK EPLTKKGETK TAERDVVVET IQMNTIFDGE
   781  AIDPVTGETY EFNSKTGARK WKDPLTQMPK WKESSHQGAA PRRVTAGEGM GSLRSANWEE
   841  DELSGKAWAE DAGLGSRNEG GKLGNPKNRN PAFMNRAYPK PHPGK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDHR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 102 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 102 nTPM
choroid plexus: 34 nTPM
lung: 15 nTPM
cerebellum: 11 nTPM
stomach: 8.7 nTPM
basal ganglia: 7.4 nTPM

Single-cell type

respiratory ciliated cells: 2,227 nCPM
fallopian tube ciliated cells: 1,066 nCPM
endometrial ciliated cells: 819 nCPM
neuroendocrine cells: 619 nCPM
ependymal cells: 490 nCPM
choroid plexus epithelial cells: 412 nCPM

Immune cell

naive B-cell: 2.9 nTPM
memory B-cell: 2 nTPM
neutrophil: 0.9 nTPM
NK-cell: 0.3 nTPM
T-reg: 0.3 nTPM
basophil: 0.1 nTPM

Brain region

choroid plexus: 101 nTPM
midbrain: 47 nTPM
medulla oblongata: 25 nTPM
pons: 20 nTPM
spinal cord: 19 nTPM
thalamus: 16 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.27
gnomAD pLI: 0
gnomAD missense Z: -0.13
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDHR3 as an antibody target. Whether an autoantibody or antibody against CDHR3 could matter depends on whether native CDHR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDHR3 is annotated at the cell surface, where native CDHR3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CDHR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...