Seroatlas · Human Serome Atlas

CDH26

Cadherin-like protein 26

Also known as: CAD26_HUMAN, VR20

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q8IXH8
Gene
CDH26
Ensembl
ENSG00000124215
Chromosome
20
Canonical length
832 aa
Protein class
Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane,Microtubules
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the cadherin protein family. Cadherins are a family of calcium-dependent adhesion molecules that mediate cell-cell adhesion in all solid tissues and modulate a wide variety of processes, including cell polarization, migration and differentiation. Cadherin domains occur as repeats in the extracellular region and are thought to contribute to the sorting of heterogeneous cell types and the maintenance of orderly structures such as epithelium. This protein is expressed in gastrointestinal epithelial cells and may be upregulated during allergic inflammation. This protein interacts with alpha integrins and may also be involved in leukocyte migration and adhesion. [provided by RefSeq, Jan 2017]

Canonical amino-acid sequenceUniProt

832 residues, UniProt reviewed canonical sequence.

>Q8IXH8|CDH26
     1  MAMRSGRHPS LLLLLVLLLW LLQVSIIDSV QQETDDLTKQ TKEKIYQPLR RSKRRWVITT
    61  LELEEEDPGP FPKLIGELFN NMSYNMSLMY LISGPGVDEY PEIGLFSLED HENGRIYVHR
   121  PVDREMTPSF TVYFDVVERS TGKIVDTSLI FNIRISDVND HAPQFPEKEF NITVQENQSA
   181  GQPIFQMLAV DLDEENTPNS QVLYFLISQT PLLKESGFRV DRLSGEIRLS GCLDYETAPQ
   241  FTLLIRARDC GEPSLSSTTT VHVDVQEGNN HRPAFTQENY KVQIPEGRAS QGVLRLLVQD
   301  RDSPFTSAWR AKFNILHGNE EGHFDISTDP ETNEGILNVI KPLDYETRPA QSLIIVVENE
   361  ERLVFCERGK LQPPRKAAAS ATVSVQVTDA NDPPAFHPQS FIVNKEEGAR PGTLLGTFNA
   421  MDPDSQIRYE LVHDPANWVS VDKNSGVVIT VEPIDRESPH VNNSFYVIII HAVDDGFPPQ
   481  TATGTLMLFL SDINDNVPTL RPRSRYMEVC ESAVHEPLHI EAEDPDLEPF SDPFTFELDN
   541  TWGNAEDTWK LGRNWGQSVE LLTLRSLPRG NYLVPLFIGD KQGLSQKQTV HVRICPCASG
   601  LTCVELADAE VGLHVGALFP VCAAFVALAV ALLFLLRCYF VLEPKRHGCS VSNDEGHQTL
   661  VMYNAESKGT SAQTWSDVEG QRPALLICTA AAGPTQGVKD LEEVPPSAAS QSAQARCALG
   721  SWGYGKPFEP RSVKNIHSTP AYPDATMHRQ LLAPVEGRMA ETLNQKLHVA NVLEDDPGYL
   781  PHVYSEEGEC GGAPSLSSLA SLEQELQPDL LDSLGSKATP FEEIYSESGV PS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDH26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.42
Highest tissue expression
7.5 nTPM

Expression across tissuesHPA

Tissue

  • prostate: 7.5 nTPM
  • tonsil: 2.8 nTPM
  • urinary bladder: 2.5 nTPM
  • esophagus: 2 nTPM
  • cervix: 1.9 nTPM
  • fallopian tube: 1.9 nTPM

Single-cell type

  • respiratory basal cells: 210 nCPM
  • respiratory secretory cells: 206 nCPM
  • respiratory deuterosomal cells: 189 nCPM
  • respiratory ciliated cells: 75 nCPM
  • prostatic hillock cells: 73 nCPM
  • prostatic glandular cells: 72 nCPM

Immune cell

  • classical monocyte: 0.2 nTPM
  • eosinophil: 0.1 nTPM
  • myeloid DC: 0.1 nTPM
  • basophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM

Brain region

  • white matter: 8.5 nTPM
  • thalamus: 7.3 nTPM
  • hypothalamus: 7.2 nTPM
  • midbrain: 7 nTPM
  • cerebral cortex: 6.9 nTPM
  • medulla oblongata: 6.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.24
gnomAD pLI
0
gnomAD missense Z
0.28
DepMap mean gene effect
0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDH26 as an antibody target. Whether an autoantibody or antibody against CDH26 could matter depends on whether native CDH26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDH26 is annotated at the cell surface, where native CDH26 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CDH26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDH26. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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