Seroatlas · Human Serome Atlas

CDH13

Cadherin-13

Also known as: CAD13_HUMAN, CDHH

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P55290
Gene
CDH13
Ensembl
ENSG00000140945
Chromosome
16
Canonical length
713 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Plasma membrane
Secretome location
Intracellular and membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a member of the cadherin superfamily. The encoded protein is localized to the surface of the cell membrane and is anchored by a GPI moiety, rather than by a transmembrane domain. The protein lacks the cytoplasmic domain characteristic of other cadherins, and so is not thought to be a cell-cell adhesion glycoprotein. This protein acts as a negative regulator of axon growth during neural differentiation. It also protects vascular endothelial cells from apoptosis due to oxidative stress, and is associated with resistance to atherosclerosis. The gene is hypermethylated in many types of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2011]

Canonical amino-acid sequenceUniProt

713 residues, UniProt reviewed canonical sequence.

>P55290|CDH13
     1  MQPRTPLVLC VLLSQVLLLT SAEDLDCTPG FQQKVFHINQ PAEFIEDQSI LNLTFSDCKG
    61  NDKLRYEVSS PYFKVNSDGG LVALRNITAV GKTLFVHART PHAEDMAELV IVGGKDIQGS
   121  LQDIFKFART SPVPRQKRSI VVSPILIPEN QRQPFPRDVG KVVDSDRPER SKFRLTGKGV
   181  DQEPKGIFRI NENTGSVSVT RTLDREVIAV YQLFVETTDV NGKTLEGPVP LEVIVIDQND
   241  NRPIFREGPY IGHVMEGSPT GTTVMRMTAF DADDPATDNA LLRYNIRQQT PDKPSPNMFY
   301  IDPEKGDIVT VVSPALLDRE TLENPKYELI IEAQDMAGLD VGLTGTATAT IMIDDKNDHS
   361  PKFTKKEFQA TVEEGAVGVI VNLTVEDKDD PTTGAWRAAY TIINGNPGQS FEIHTNPQTN
   421  EGMLSVVKPL DYEISAFHTL LIKVENEDPL VPDVSYGPSS TATVHITVLD VNEGPVFYPD
   481  PMMVTRQEDL SVGSVLLTVN ATDPDSLQHQ TIRYSVYKDP AGWLNINPIN GTVDTTAVLD
   541  RESPFVDNSV YTALFLAIDS GNPPATGTGT LLITLEDVND NAPFIYPTVA EVCDDAKNLS
   601  VVILGASDKD LHPNTDPFKF EIHKQAVPDK VWKISKINNT HALVSLLQNL NKANYNLPIM
   661  VTDSGKPPMT NITDLRVQVC SCRNSKVDCN AAGALRFSLP SVLLLSLFSL ACL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDH13 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
141 nTPM

Expression across tissuesHPA

Tissue

  • blood vessel: 141 nTPM
  • skeletal muscle: 64 nTPM
  • tongue: 54 nTPM
  • heart muscle: 54 nTPM
  • cervix: 40 nTPM
  • endometrium: 39 nTPM

Single-cell type

  • myonuclei: 2,265 nCPM
  • cardiomyocytes: 1,835 nCPM
  • thymic myoid cells: 1,326 nCPM
  • myosatellite cells: 613 nCPM
  • oligodendrocyte progenitor cells: 597 nCPM
  • salivary myoepithelial cells: 366 nCPM

Immune cell

  • non-classical monocyte: 4.3 nTPM
  • intermediate monocyte: 2.1 nTPM
  • eosinophil: 1.4 nTPM
  • basophil: 1 nTPM
  • neutrophil: 1 nTPM
  • classical monocyte: 0.5 nTPM

Brain region

  • hypothalamus: 65 nTPM
  • cerebral cortex: 64 nTPM
  • basal ganglia: 63 nTPM
  • amygdala: 60 nTPM
  • spinal cord: 33 nTPM
  • midbrain: 31 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDH13.

Disease | ImmuneIEDB

Conditions an epitope on CDH13 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.59
gnomAD pLI
0
gnomAD missense Z
-0.53
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDH13 as an antibody target. Whether an autoantibody or antibody against CDH13 could matter depends on whether native CDH13 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDH13 is annotated at the cell surface, where native CDH13 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CDH13 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDH13. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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