Seroatlas · Human Serome Atlas

CDCP2

CUB domain-containing protein 2

Also known as: CDCP2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5VXM1
Gene: CDCP2
Ensembl: ENSG00000157211
Chromosome: 1
Canonical length: 540 aa
Protein class: Predicted membrane proteins, Predicted secreted proteins
Secretome location: Secreted - unknown location

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

540 residues, UniProt reviewed canonical sequence.

>Q5VXM1|CDCP2
     1  MLAEWGACLL LAVALLGPGL QAQAMEGVKC GGVLSAPSGN FSSPNFPRLY PYNTECSWLI
    61  VVAEGSSVLL TFHAFDLEYH DTCSFDFLEI YNGASPDKGN LLGRFCGKVP PPPFTSSWHV
   121  MSVIFHSDKH VASHGFSAGY QKDVCGGVLT GLSGVLTSPE YPNNYPNSME CHWVIRAAGP
   181  AHVKLVFVDF QVEGNEECTY DYVAVLGGPG PTRGHHYCGS TRPPTLVSLG HELQVVFKSD
   241  FNIGGRGFKA YYFSGECQEV YMAMRGNFSS PQYPSSYPNN IRCHWTIRLP PGYQVKVFFL
   301  DLDLEEPNSL TKTCDFDHLA AFDGASEEAP LLGNWCGHHL PPPVTSSHNQ LLLLLHTDRS
   361  TTRRGFSVAY IGVVPMNVSC SRTDFQILIS TQALAPLERT KVYLGSRSCA AQEVGGNLRI
   421  QARFDTCGTE SQRRNNTSVI VSVLYIDFSA AGREDIHEYE VRCEPRRKEA SVHLLSGSHW
   481  LGPYAATAEH LQEAPPMDEA EALEGPVSMV AQDTSDIVFL GLCILAGILM VIAIVVLMLL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDCP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 0.1 nTPM

Expression across tissuesHPA

Tissue

adipose tissue: 0.1 nTPM
breast: 0.1 nTPM
cerebral cortex: 0.1 nTPM
cervix: 0.1 nTPM
choroid plexus: 0.1 nTPM
spleen: 0.1 nTPM

Single-cell type

astrocytes: 0.1 nCPM
brain excitatory neurons: 0.1 nCPM
brain inhibitory neurons: 0.1 nCPM
oligodendrocytes: 0.1 nCPM
adipocytes: 0 nCPM
adrenal cortex cells: 0 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.7 nTPM
amygdala: 0.5 nTPM
basal ganglia: 0.4 nTPM
hippocampal formation: 0.4 nTPM
white matter: 0.3 nTPM
hypothalamus: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.79
gnomAD pLI: 0
gnomAD missense Z: 0.02
DepMap mean gene effect: -0.15
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDCP2 as an antibody target. Whether an autoantibody or antibody against CDCP2 could matter depends on whether native CDCP2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDCP2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDCP2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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