Seroatlas · Human Serome Atlas

CDCA7

Cell division cycle-associated protein 7

Also known as: CDCA7_HUMAN, FLJ14736, JPO1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BWT1
Gene: CDCA7
Ensembl: ENSG00000144354
Chromosome: 2
Canonical length: 371 aa
Protein class: Disease related genes, Human disease related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

371 residues, UniProt reviewed canonical sequence.

>Q9BWT1|CDCA7
     1  MDARRVPQKD LRVKKNLKKF RYVKLISMET SSSSDDSCDS FASDNFANTR LQSVREGCRT
    61  RSQCRHSGPL RVAMKFPARS TRGATNKKAE SRQPSENSVT DSNSDSEDES GMNFLEKRAL
   121  NIKQNKAMLA KLMSELESFP GSFRGRHPLP GSDSQSRRPR RRTFPGVASR RNPERRARPL
   181  TRSRSRILGS LDALPMEEEE EEDKYMLVRK RKTVDGYMNE DDLPRSRRSR SSVTLPHIIR
   241  PVEEITEEEL ENVCSNSREK IYNRSLGSTC HQCRQKTIDT KTNCRNPDCW GVRGQFCGPC
   301  LRNRYGEEVR DALLDPNWHC PPCRGICNCS FCRQRDGRCA TGVLVYLAKY HGFGNVHAYL
   361  KSLKQEFEMQ A

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDCA7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.55
Highest tissue expression: 42 nTPM

Expression across tissuesHPA

Tissue

thymus: 42 nTPM
tonsil: 34 nTPM
lymph node: 29 nTPM
small intestine: 27 nTPM
duodenum: 23 nTPM
rectum: 23 nTPM

Single-cell type

enteric stem cells: 207 nCPM
paneth cells: 170 nCPM
enteric transient amplifying cells: 110 nCPM
gastric progenitor cells: 104 nCPM
leydig cells: 93 nCPM
decidual stromal cells: 63 nCPM

Immune cell

T-reg: 8.8 nTPM
memory CD8 T-cell: 6.1 nTPM
myeloid DC: 3.8 nTPM
NK-cell: 3.6 nTPM
memory CD4 T-cell: 3.2 nTPM
total PBMC: 2.5 nTPM

Brain region

choroid plexus: 12 nTPM
hypothalamus: 2.1 nTPM
thalamus: 2 nTPM
white matter: 1.8 nTPM
midbrain: 1.5 nTPM
medulla oblongata: 1.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CDCA7.

Disease | AllUniProt

Conditions CDCA7 is implicated in, by any mechanism.

Immunodeficiency-centromeric instability-facial anomalies syndrome 3 (ICF3) MIM:616910

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 289 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Immunodeficiency-centromeric instability-facial anomalies syndrome 3

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.58
gnomAD pLI: 0.01
gnomAD missense Z: 1.59
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

hemi-methylated DNA-binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CDCA7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDCA7 as an antibody target. Whether an autoantibody or antibody against CDCA7 could matter depends on whether native CDCA7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDCA7 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDCA7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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