Seroatlas · Human Serome Atlas

CDC20B

Cell division cycle protein 20 homolog B

Also known as: CD20B_HUMAN, FLJ37927

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q86Y33
Gene
CDC20B
Ensembl
ENSG00000164287
Chromosome
5
Canonical length
519 aa
Protein class
Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable anaphase-promoting complex binding activity and ubiquitin ligase activator activity. Involved in de novo centriole assembly. Located in deuterosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

519 residues, UniProt reviewed canonical sequence.

>Q86Y33|CDC20B
     1  MEWKLERTAP RRVRTEEEML WESIMRVLSK DLKQKRSQDS ANVLDSVNAT YSDFKSNFAK
    61  RLSAEVPVAS SPITTRWQQS QTRALSSDSF GEEQSTTYLP EASGSVLKTP PEKETLTLGS
   121  RKEQLKTPSK GISETSNSAL HFCKAPHAMD RDWKESVASK GQKCLKQLFV TQNVVQQANG
   181  KMQLCEQSEC VWKGCKDGVR DESFHLKSSG DINDSILQPE VKIHITGLRN DYYLNILDWS
   241  FQNLVAIALG SAVYIWNGEN HNGIENIDLS LTCNYISSVS WIKEGTCLAV GTSEGEVQLW
   301  DVVTKKRLRN MLGHLSVVGA LSWNHFILSS GSRLGRVYHH DVRVAQHHVG TLRHKQAVCA
   361  LKWSPDGRLL SSGCSDGLLT IWPHDPGASA QGQPLKVITQ STAVKAMDWC PWQSGVLAIG
   421  GGMKDGRLHI LDINAGKSIQ TPSTNSQICS LIWLPKTKEI ATGQGTPKND VTVWTCPTVS
   481  RSGGFFGHRG RVLHLSLSPD QTRVFSAAAD GTASVWNCY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC20B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.39
Highest tissue expression
2.4 nTPM

Expression across tissuesHPA

Tissue

  • testis: 2.4 nTPM
  • fallopian tube: 1.9 nTPM
  • kidney: 1 nTPM
  • endometrium: 0.6 nTPM
  • choroid plexus: 0.3 nTPM
  • lung: 0.3 nTPM

Single-cell type

  • respiratory deuterosomal cells: 3,831 nCPM
  • respiratory secretory cells: 70 nCPM
  • endometrial ciliated cells: 56 nCPM
  • epicardial cells: 14 nCPM
  • epididymal clear cells: 12 nCPM
  • fallopian tube ciliated cells: 12 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • choroid plexus: 0.5 nTPM
  • cerebral cortex: 0.2 nTPM
  • white matter: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.1
gnomAD pLI
0
gnomAD missense Z
0.54
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC20B as an antibody target. Whether an autoantibody or antibody against CDC20B could matter depends on whether native CDC20B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC20B is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDC20B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CDC20B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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