Seroatlas · Human Serome Atlas

CDC14C

Dual specificity protein phosphatase CDC14C

Also known as: CC14C_HUMAN, CDC14B2, CDC14Bretro, CDC14CP, MGC26484

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A4D256
Gene: CDC14C
Ensembl: ENSG00000218305
Chromosome: 7
Canonical length: 447 aa
Protein class: Enzymes, Predicted membrane proteins

OverviewNCBI Gene

This gene represents a retrogene of cell division cycle 14B (CDC14B), which is located on chromosome 9. The introns in the coding sequence have been processed out relative to the CDC14B locus, but there is an intact open reading frame that is missing only some sequence at the N-terminus, including the nuclear localiztion signal, relative to proteins encoded by the CDC14B gene. There is a difference in the subcellular localization of the protein encoded by this gene, relative to its parental gene product. While the parental gene product displays microtubular localization, GFP chimeras of the protein encoded by this gene localize to the endoplasmic reticulum, indicating a possible new functional role for this gene. [provided by RefSeq, Nov 2017]

Canonical amino-acid sequenceUniProt

447 residues, UniProt reviewed canonical sequence.

>A4D256|CDC14C
     1  MRSSTLQDPR RRDPQDDVYV DITDRLRFAI LYSRPKSASN VHYFSIDNEL EYENFSEDFG
    61  PLNLAMVYRY CCKINKKLKS ITMLRKKIVH FTGSDQRKQA NAAFLVGCYM VIYLGRTPEA
   121  AYRILIFGDT PYIPFRDAAY GSCNFYITLL DCFHAVKKAM QYGFLNFNSF NLDEYEHYEK
   181  AENGDLNWII PDRFIAFCGP HSRARLESGY HQHSPETYIQ YFKNHNVTTI IRLNKRMYDA
   241  KRFTDAGFDH HDLFFADGST PTDAIVKRFL DICENAEGAI AVHCKAGLGR TGTLIACYIM
   301  KHYRMTAAET IAWVRICRPG LVIGPQQQFL VMKQTSLWLE GDYFRQRLKG QENGQHRAAF
   361  SKLLSGVDDI SINGVENQDQ QEPKPYSDDD EINGVTQGDR SRALKRRRQS KTNDILLPSP
   421  LAVLTFTLCS VVIWWIVCDY ILPILLF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC14C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.3
Highest tissue expression: 7 nTPM

Expression across tissuesHPA

Tissue

testis: 7 nTPM
retina: 4.1 nTPM
bone marrow: 1.2 nTPM
pancreas: 1.2 nTPM
salivary gland: 0.8 nTPM
adipose tissue: 0.6 nTPM

Single-cell type

late primary spermatocytes: 47 nCPM
late spermatids: 11 nCPM
early spermatids: 5.4 nCPM
early primary spermatocytes: 0.4 nCPM
bergmann glia: 0.1 nCPM
oligodendrocyte progenitor cells: 0.1 nCPM

Immune cell

basophil: 0.5 nTPM
naive B-cell: 0.4 nTPM
memory B-cell: 0.3 nTPM
naive CD4 T-cell: 0.3 nTPM
naive CD8 T-cell: 0.3 nTPM
neutrophil: 0.3 nTPM

Brain region

cerebellum: 8.8 nTPM
cerebral cortex: 7.4 nTPM
white matter: 7.4 nTPM
hippocampal formation: 7.1 nTPM
hypothalamus: 7.1 nTPM
choroid plexus: 7 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDC14C as an antibody target. Whether an autoantibody or antibody against CDC14C could matter depends on whether native CDC14C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDC14C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDC14C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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