CDC14B

Protein identityUniProt · HPA

UniProt accession

O60729

Gene

CDC14B

Ensembl

ENSG00000081377

Chromosome

9

Canonical length

498 aa

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins

Subcellular location

Nucleoplasm,Cell Junctions,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. This protein is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, which suggests the role in cell cycle control. This protein has been shown to interact with and dephosphorylates tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splice of this gene results in 3 transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

498 residues, UniProt reviewed canonical sequence.

>O60729|CDC14B
     1  MKRKSERRSS WAAAPPCSRR CSSTSPGVKK IRSSTQQDPR RRDPQDDVYL DITDRLCFAI
    61  LYSRPKSASN VHYFSIDNEL EYENFYADFG PLNLAMVYRY CCKINKKLKS ITMLRKKIVH
   121  FTGSDQRKQA NAAFLVGCYM VIYLGRTPEE AYRILIFGET SYIPFRDAAY GSCNFYITLL
   181  DCFHAVKKAM QYGFLNFNSF NLDEYEHYEK AENGDLNWII PDRFIAFCGP HSRARLESGY
   241  HQHSPETYIQ YFKNHNVTTI IRLNKRMYDA KRFTDAGFDH HDLFFADGST PTDAIVKEFL
   301  DICENAEGAI AVHCKAGLGR TGTLIACYIM KHYRMTAAET IAWVRICRPG SVIGPQQQFL
   361  VMKQTNLWLE GDYFRQKLKG QENGQHRAAF SKLLSGVDDI SINGVENQDQ QEPEPYSDDD
   421  EINGVTQGDR LRALKSRRQS KTNAIPLTVI LQSSVQSCKT SEPNISGSAG ITKRTTRSAS
   481  RKSSVKSLSI SRTKTVLR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDC14B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.36

Highest tissue expression

12 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.34

gnomAD pLI

0.94

gnomAD missense Z

1.01

DepMap mean gene effect

-0.07

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cilium assembly
• DNA repair
• microtubule cytoskeleton organization
• mitotic G2 DNA damage checkpoint signaling
• positive regulation of cytokinesis
• positive regulation of ubiquitin protein ligase activity
• protein dephosphorylation
• regulation of exit from mitosis

Molecular functions

• protein serine/threonine phosphatase activity
• protein tyrosine phosphatase activity

Cellular components

• cell junction
• cytoplasm
• cytosol
• mitotic spindle
• nucleolus
• nucleoplasm
• nucleus
• spindle pole

Protein domainsUniProt · Pfam · InterPro

• Tyrosine-specific protein phosphatases domain
• Protein-tyrosine phosphatase, catalytic
• Protein-tyrosine phosphatase, active site
• Dual specificity protein phosphatase domain
• Protein-tyrosine phosphatase-like
• Dual specificity/tyrosine protein phosphatase, N-terminal
• Dual-specificity phosphatase CDC14, C-terminal
• Protein Tyrosine Phosphatase
• Dual specificity protein phosphatase, N-terminal half
• Polymorphic toxin system, DSP-PTPase phosphatase

KeywordsUniProt

• DNA damage
• DNA repair
• Hydrolase
• Nucleus
• Protein phosphatase

InteractionsUniProt · HPA

Protein binding partners of CDC14B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• MSH2