Seroatlas · Human Serome Atlas

CDADC1

Cytidine and dCMP deaminase domain-containing protein 1

Also known as: CDAC1_HUMAN, NYD-SP15

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9BWV3
Gene: CDADC1
Ensembl: ENSG00000102543
Chromosome: 13
Canonical length: 514 aa
Protein class: Enzymes, Predicted intracellular proteins
Subcellular location: Nucleoplasm

OverviewNCBI Gene

Enables several functions, including cytidine deaminase activity; importin-alpha family protein binding activity; and protein homodimerization activity. Involved in DNA cytosine deamination and cytidine deamination. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2025]

Canonical amino-acid sequenceUniProt

514 residues, UniProt reviewed canonical sequence.

>Q9BWV3|CDADC1
     1  MKEAGQMQNL ESARAGRSVS TQTGSMTGQI PRLSKVNLFT LLSLWMELFP AEAQRQKSQK
    61  NEEGKHGPLG DNEERTRVST DKRQVKRTGL VVVKNMKIVG LHCSSEDLHA GQIALIKHGS
   121  RLKNCDLYFS RKPCSACLKM IVNAGVNRIS YWPADPEISL LTEASSSEDA KLDAKAVERL
   181  KSNSRAHVCV LLQPLVCYMV QFVEETSYKC DFIQKITKTL PDANTDFYYE CKQERIKEYE
   241  MLFLVSNEEM HKQILMTIGL ENLCENPYFS NLRQNMKDLI LLLATVASSV PNFKHFGFYR
   301  SNPEQINEIH NQSLPQEIAR HCMVQARLLA YRTEDHKTGV GAVIWAEGKS RSCDGTGAMY
   361  FVGCGYNAFP VGSEYADFPH MDDKQKDREI RKFRYIIHAE QNALTFRCQE IKPEERSMIF
   421  VTKCPCDECV PLIKGAGIKQ IYAGDVDVGK KKADISYMRF GELEGVSKFT WQLNPSGAYG
   481  LEQNEPERRE NGVLRPVPQK EEQHQDKKLR LGIH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDADC1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.31
Highest tissue expression: 8.9 nTPM

Expression across tissuesHPA

Tissue

kidney: 8.9 nTPM
thyroid gland: 8.8 nTPM
liver: 7.6 nTPM
testis: 7.5 nTPM
adrenal gland: 6.4 nTPM
cerebellum: 6.1 nTPM

Single-cell type

neutrophil progenitors: 484 nCPM
neutrophils: 451 nCPM
early spermatids: 232 nCPM
hematopoietic stem cells: 209 nCPM
late spermatids: 84 nCPM
early primary spermatocytes: 66 nCPM

Immune cell

basophil: 9.9 nTPM
memory CD8 T-cell: 1.9 nTPM
non-classical monocyte: 1.9 nTPM
T-reg: 1.6 nTPM
MAIT T-cell: 1.5 nTPM
gdT-cell: 1.4 nTPM

Brain region

choroid plexus: 7.7 nTPM
cerebellum: 7.5 nTPM
thalamus: 7.4 nTPM
hypothalamus: 7 nTPM
midbrain: 6.9 nTPM
cerebral cortex: 6.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0
gnomAD missense Z: 1.47
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

DNA cytosine deamination

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDADC1 as an antibody target. Whether an autoantibody or antibody against CDADC1 could matter depends on whether native CDADC1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDADC1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CDADC1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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