CDA

Protein identityUniProt · HPA

UniProt accession

P32320

Gene

CDA

Ensembl

ENSG00000158825

Chromosome

1

Canonical length

146 aa

Protein class

Enzymes, FDA approved drug targets, Metabolic proteins, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoplasm

Quaternary structure

Homotetramer

OverviewNCBI Gene

This gene encodes an enzyme involved in pyrimidine salvaging. The encoded protein forms a homotetramer that catalyzes the irreversible hydrolytic deamination of cytidine and deoxycytidine to uridine and deoxyuridine, respectively. It is one of several deaminases responsible for maintaining the cellular pyrimidine pool. Mutations in this gene are associated with decreased sensitivity to the cytosine nucleoside analogue cytosine arabinoside used in the treatment of certain childhood leukemias. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

146 residues, UniProt reviewed canonical sequence.

>P32320|CDA
     1  MAQKRPACTL KPECVQQLLV CSQEAKKSAY CPYSHFPVGA ALLTQEGRIF KGCNIENACY
    61  PLGICAERTA IQKAVSEGYK DFRAIAIASD MQDDFISPCG ACRQVMREFG TNWPVYMTKP
   121  DGTYIVMTVQ ELLPSSFGPE DLQKTQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDA can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

183 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.32

gnomAD pLI

0.01

gnomAD missense Z

0.3

DepMap mean gene effect

0.11

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cellular response to external biotic stimulus
• CMP catabolic process
• cytosine metabolic process
• dCMP catabolic process
• UMP salvage
• pyrimidine-containing compound salvage

Molecular functions

• cytidine deaminase activity
• identical protein binding
• nucleoside binding
• protein homodimerization activity
• zinc ion binding

Cellular components

• cytosol
• extracellular region
• ficolin-1-rich granule lumen
• secretory granule lumen
• tertiary granule lumen

Protein domainsUniProt · Pfam · InterPro

• Cytidine and deoxycytidylate deaminase domain
• APOBEC/CMP deaminase, zinc-binding
• Cytidine deaminase-like
• Cytidine and deoxycytidylate deaminase zinc-binding region
• Cytidine deaminase, homotetrameric
• Cytidine and Deoxycytidylate Deaminase

KeywordsUniProt

• Hydrolase
• Metal-binding
• Zinc