Seroatlas · Human Serome Atlas

CD8B2

T-cell surface glycoprotein CD8 beta-2 chain

Also known as: CD8B2_HUMAN, CD8BP

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NJW9
Gene
CD8B2
Ensembl
ENSG00000254126
Chromosome
2
Canonical length
210 aa
Protein class
Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable MHC class I protein binding activity and coreceptor activity. Predicted to be involved in adaptive immune response and regulation of immune response. Predicted to be located in plasma membrane. Predicted to be active in cell surface. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

210 residues, UniProt reviewed canonical sequence.

>A6NJW9|CD8B2
     1  MRPRLWLLLA AQLTVLHGNS VLQQTPAYIK VQTNKMVMLS CEAKISLSNM CIYWLRQRQA
    61  PSSDSHHEFL TLWDSAKGTI HGEEVEQEKI AVFRDASRFI LNLTSVKPED SGIYFCMIVG
   121  SPELTFGKGT QLSVVDFLPT TAQPTKKSTL KKRVCRLPRP ETQKGPLCSP VTLGLLVAGV
   181  LVLLVSLGVA MHLCCRRRRA RLRFMKQFYK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD8B2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
6.9 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 6.9 nTPM
  • tonsil: 5.3 nTPM
  • midbrain: 2.1 nTPM
  • basal ganglia: 1.8 nTPM
  • kidney: 1.8 nTPM
  • lymph node: 1.8 nTPM

Single-cell type

  • gonadotrophs: 6.4 nCPM
  • retinal ganglion cells: 3.9 nCPM
  • basal prostatic cells: 2.7 nCPM
  • epididymal clear cells: 2 nCPM
  • mesothelial cells: 1.6 nCPM
  • submucosal glandular cells: 1.6 nCPM

Immune cell

  • naive CD8 T-cell: 31 nTPM
  • memory CD8 T-cell: 19 nTPM
  • total PBMC: 12 nTPM
  • MAIT T-cell: 2.8 nTPM
  • basophil: 2.1 nTPM
  • gdT-cell: 0.6 nTPM

Brain region

  • pons: 5.6 nTPM
  • medulla oblongata: 3.9 nTPM
  • thalamus: 3.9 nTPM
  • midbrain: 3.1 nTPM
  • cerebral cortex: 2.4 nTPM
  • spinal cord: 2.3 nTPM

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD8B2 as an antibody target. Whether an autoantibody or antibody against CD8B2 could matter depends on whether native CD8B2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD8B2 is annotated at the cell surface, where native CD8B2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD8B2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD8B2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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