Seroatlas · Human Serome Atlas

CD70

CD70 antigen

Also known as: CD27L, CD27LG, CD70_HUMAN, TNFSF7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P32970
Gene
CD70
Ensembl
ENSG00000125726
Chromosome
19
Canonical length
193 aa
Protein class
Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm
Quaternary structure
Homotrimer

OverviewNCBI Gene

The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

193 residues, UniProt reviewed canonical sequence.

>P32970|CD70
     1  MPEEGSGCSV RRRPYGCVLR AALVPLVAGL VICLVVCIQR FAQAQQQLPL ESLGWDVAEL
    61  QLNHTGPQQD PRLYWQGGPA LGRSFLHGPE LDKGQLRIHR DGIYMVHIQV TLAICSSTTA
   121  SRHHPTTLAV GICSPASRSI SLLRLSFHQG CTIASQRLTP LARGDTLCTN LTGTLLPSRN
   181  TDETFFGVQW VRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD70 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
3.2 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 3.2 nTPM
  • appendix: 3 nTPM
  • spleen: 2.8 nTPM
  • adipose tissue: 2.3 nTPM
  • colon: 2.1 nTPM
  • small intestine: 2.1 nTPM

Single-cell type

  • b-cells: 76 nCPM
  • plasma cells: 36 nCPM
  • t-cells: 33 nCPM
  • epididymal basal cells: 26 nCPM
  • epididymal efferent duct ciliated cells: 18 nCPM
  • fibroblasts: 14 nCPM

Immune cell

  • T-reg: 44 nTPM
  • memory B-cell: 24 nTPM
  • naive B-cell: 9.9 nTPM
  • memory CD8 T-cell: 8.8 nTPM
  • MAIT T-cell: 8.1 nTPM
  • memory CD4 T-cell: 5.3 nTPM

Brain region

  • cerebellum: 1.5 nTPM
  • white matter: 1.2 nTPM
  • cerebral cortex: 1.1 nTPM
  • choroid plexus: 1.1 nTPM
  • hypothalamus: 1.1 nTPM
  • medulla oblongata: 0.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CD70.

Disease | AllUniProt

Conditions CD70 is implicated in, by any mechanism.

Disease | GeneticClinVar

3 pathogenic / likely-pathogenic of 49 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

  • Severe combined immunodeficiency due to CD70 deficiency

ReferencesPubMed · IEDB

Publications for CD70 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Reference: AutoantibodyPubMed

1 publication

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.75
gnomAD pLI
0.01
gnomAD missense Z
0.8
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD70 as an antibody target. Whether an autoantibody or antibody against CD70 could matter depends on whether native CD70 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD70 is annotated at the cell surface, where native CD70 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD70 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD70. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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