Seroatlas · Human Serome Atlas

CD52

CAMPATH-1 antigen

Also known as: CD52_HUMAN, CDW52, EDDM5, HE5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P31358
Gene
CD52
Ensembl
ENSG00000169442
Chromosome
1
Canonical length
61 aa
Protein class
Cancer-related genes, CD markers, FDA approved drug targets, Predicted membrane proteins

OverviewNCBI Gene

Involved in positive regulation of cytosolic calcium ion concentration. Predicted to be located in extracellular region and plasma membrane. Predicted to be active in sperm midpiece. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

61 residues, UniProt reviewed canonical sequence.

>P31358|CD52
     1  MKRFLFLLLT ISLLVMVQIQ TGLSGQNDTS QTSSPSASSN ISGGIFLFFV ANAIIHLFCF
    61  S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD52 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.49
Highest tissue expression
34,114 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 34,114 nTPM
  • tonsil: 1,173 nTPM
  • lymph node: 1,009 nTPM
  • thymus: 978 nTPM
  • spleen: 623 nTPM
  • lung: 422 nTPM

Single-cell type

  • epididymal principal cells: 28,428 nCPM
  • b-cells: 1,002 nCPM
  • t-cells: 754 nCPM
  • innate lymphoid cells: 523 nCPM
  • mast cells: 459 nCPM
  • epididymal basal cells: 424 nCPM

Immune cell

  • total PBMC: 22,625 nTPM
  • T-reg: 11,722 nTPM
  • memory B-cell: 10,619 nTPM
  • naive B-cell: 10,120 nTPM
  • eosinophil: 9,811 nTPM
  • memory CD4 T-cell: 8,206 nTPM

Brain region

  • thalamus: 15 nTPM
  • cerebral cortex: 11 nTPM
  • choroid plexus: 7.2 nTPM
  • medulla oblongata: 4.3 nTPM
  • basal ganglia: 3.3 nTPM
  • white matter: 3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CD52.

Disease | AutoantibodyPubMed

Conditions in which antibodies against CD52 are reported. Each links to that disease's full target list.

    Showing 0 of 1 — disease pages carrying at least 10 antigens.

    ReferencesPubMed · IEDB

    Publications for CD52 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

    Reference: AutoantibodyPubMed

    11 publications

    Show 6 more

    Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

    Genetic constraint and essentialitygnomAD · DepMap

    Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

    gnomAD LOEUF (loss-of-function intolerance)
    1.7
    gnomAD pLI
    0.4
    gnomAD missense Z
    0.51
    DepMap mean gene effect
    -0.08
    DepMap dependency class
    none

    Cancer expressionTCGA

    Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

    OntologyGO

    Biological processes

    Cellular components

    Protein domainsUniProt · Pfam · InterPro

    • CAMPATH-1 antigen (CD52)
    • CAMPATH-1 antigen

    KeywordsUniProt

    Antibody and autoantibody relevanceSeroatlas analysis

    Seroatlas reads CD52 as an antibody target. Whether an autoantibody or antibody against CD52 could matter depends on whether native CD52 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

    CD52 is annotated at the cell surface, where native CD52 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

    Annotation status

    The present source text does not explicitly label CD52 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

    Canonical record: https://seroatlas.com/gene/CD52. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

    Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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