CD300LF

Protein identityUniProt · HPA

UniProt accession

Q8TDQ1

Gene

CD300LF

Ensembl

ENSG00000186074

Chromosome

17

Canonical length

290 aa

Protein class

CD markers, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the CD300 protein family. Members of this family are cell surface glycoproteins with a single IgV-like extracellular domain, and are involved in the regulation of immune response. The encoded protein is an inhibitory receptor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Canonical amino-acid sequenceUniProt

290 residues, UniProt reviewed canonical sequence.

>Q8TDQ1|CD300LF
     1  MPLLTLYLLL FWLSGYSIVT QITGPTTVNG LERGSLTVQC VYRSGWETYL KWWCRGAIWR
    61  DCKILVKTSG SEQEVKRDRV SIKDNQKNRT FTVTMEDLMK TDADTYWCGI EKTGNDLGVT
   121  VQVTIDPAPV TQEETSSSPT LTGHHLDNRH KLLKLSVLLP LIFTILLLLL VAASLLAWRM
   181  MKYQQKAAGM SPEQVLQPLE GDLCYADLTL QLAGTSPQKA TTKLSSAQVD QVEVEYVTMA
   241  SLPKEDISYA SLTLGAEDQE PTYCNMGHLS SHLPGRGPEE PTEYSTISRP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD300LF can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.52

Highest tissue expression

29 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.44

gnomAD pLI

0

gnomAD missense Z

0.36

DepMap mean gene effect

0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• immune response-activating signaling pathway
• interleukin-13-mediated signaling pathway
• negative regulation of apoptotic cell clearance
• negative regulation of mast cell activation
• negative regulation of MyD88-dependent toll-like receptor signaling pathway
• positive regulation of apoptotic cell clearance
• positive regulation of interleukin-4-mediated signaling pathway
• TRIF-dependent toll-like receptor signaling pathway

Molecular functions

• ceramide binding
• identical protein binding
• interleukin-4 receptor binding
• phosphatidylserine binding
• transmembrane signaling receptor activity

Cellular components

• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Immunoglobulin V-set domain
• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• CD300 family immune receptors
• Immunoglobulin V-set domain
• SHP2-interacting transmembrane adaptor protein, SIT

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Glycoprotein
• Immunity
• Immunoglobulin domain
• Lipid-binding
• Membrane
• Phosphoprotein
• Receptor
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of CD300LF in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• IL4R
• PTPN6