Seroatlas · Human Serome Atlas

CD300C

CMRF35-like molecule 6

Also known as: CLM6_HUMAN, CMRF-35A, CMRF35, CMRF35A, IGSF16, LIR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q08708
Gene: CD300C
Ensembl: ENSG00000167850
Chromosome: 17
Canonical length: 224 aa
Protein class: CD markers, Predicted membrane proteins
Subcellular location: Golgi apparatus,Vesicles,Mitochondria

OverviewNCBI Gene

The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

224 residues, UniProt reviewed canonical sequence.

>Q08708|CD300C
     1  MTARAWASWR SSALLLLLVP GYFPLSHPMT VAGPVGGSLS VQCRYEKEHR TLNKFWCRPP
    61  QILRCDKIVE TKGSAGKRNG RVSIRDSPAN LSFTVTLENL TEEDAGTYWC GVDTPWLRDF
   121  HDPIVEVEVS VFPAGTTTAS SPQSSMGTSG PPTKLPVHTW PSVTRKDSPE PSPHPGSLFS
   181  NVRFLLLVLL ELPLLLSMLG AVLWVNRPQR SSRSRQNWPK GENQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD300C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.5
Highest tissue expression: 9.2 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 9.2 nTPM
lung: 7.9 nTPM
spleen: 6.9 nTPM
appendix: 6.4 nTPM
adipose tissue: 3.7 nTPM
urinary bladder: 3.6 nTPM

Single-cell type

hofbauer cells: 37 nCPM
monocytes: 32 nCPM
kupffer cells: 31 nCPM
macrophages: 17 nCPM
cdc: 14 nCPM
monocyte progenitors: 11 nCPM

Immune cell

non-classical monocyte: 244 nTPM
intermediate monocyte: 229 nTPM
myeloid DC: 159 nTPM
classical monocyte: 142 nTPM
total PBMC: 65 nTPM
basophil: 52 nTPM

Brain region

cerebral cortex: 12 nTPM
thalamus: 6 nTPM
white matter: 4.4 nTPM
pons: 4.3 nTPM
midbrain: 3.4 nTPM
medulla oblongata: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.57
gnomAD pLI: 0
gnomAD missense Z: 0.43
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transmembrane signaling receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD300C as an antibody target. Whether an autoantibody or antibody against CD300C could matter depends on whether native CD300C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD300C is annotated at the cell surface, where native CD300C is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

The CMRF35 antigen, which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes (Jackson et al., 1992 [PubMed 1349532]).[supplied by OMIM, Mar 2008]

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