Seroatlas · Human Serome Atlas

CD300A

CMRF35-like molecule 8

Also known as: CLM8_HUMAN, CMRF-35-H9, CMRF35H, IGSF12, IRC1, IRC2, Irp60

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UGN4
Gene
CD300A
Ensembl
ENSG00000167851
Chromosome
17
Canonical length
299 aa
Protein class
CD markers, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Vesicles,Plasma membrane,Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the CD300 glycoprotein family of cell surface proteins found on leukocytes involved in immune response signaling pathways. This gene is located on chromosome 17 in a cluster with all but one of the other family members. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]

Canonical amino-acid sequenceUniProt

299 residues, UniProt reviewed canonical sequence.

>Q9UGN4|CD300A
     1  MWLPWALLLL WVPGCFALSK CRTVAGPVGG SLSVQCPYEK EHRTLNKYWC RPPQIFLCDK
    61  IVETKGSAGK RNGRVSIRDS PANLSFTVTL ENLTEEDAGT YWCGVDTPWL RDFHDPVVEV
   121  EVSVFPASTS MTPASITAAK TSTITTAFPP VSSTTLFAVG ATHSASIQEE TEEVVNSQLP
   181  LLLSLLALLL LLLVGASLLA WRMFQKWIKA GDHSELSQNP KQAATQSELH YANLELLMWP
   241  LQEKPAPPRE VEVEYSTVAS PREELHYASV VFDSNTNRIA AQRPREEEPD SDYSVIRKT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD300A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.55
Highest tissue expression
95 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 95 nTPM
  • appendix: 29 nTPM
  • lymph node: 25 nTPM
  • bone marrow: 23 nTPM
  • lung: 18 nTPM
  • choroid plexus: 15 nTPM

Single-cell type

  • hofbauer cells: 149 nCPM
  • neutrophils: 125 nCPM
  • kupffer cells: 114 nCPM
  • nk-cells: 100 nCPM
  • macrophages: 93 nCPM
  • pdcs: 90 nCPM

Immune cell

  • basophil: 847 nTPM
  • neutrophil: 563 nTPM
  • eosinophil: 483 nTPM
  • NK-cell: 458 nTPM
  • non-classical monocyte: 390 nTPM
  • intermediate monocyte: 375 nTPM

Brain region

  • cerebral cortex: 60 nTPM
  • pons: 19 nTPM
  • thalamus: 18 nTPM
  • white matter: 17 nTPM
  • medulla oblongata: 15 nTPM
  • spinal cord: 11 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
0.23
DepMap mean gene effect
0.09
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD300A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD300A as an antibody target. Whether an autoantibody or antibody against CD300A could matter depends on whether native CD300A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD300A is annotated at the cell surface, where native CD300A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD300A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD300A. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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