Seroatlas · Human Serome Atlas

CD200R1L

Cell surface glycoprotein CD200 receptor 2

Also known as: CD200R2, CD200RLa, MO2R2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6Q8B3
Gene: CD200R1L
Ensembl: ENSG00000206531
Chromosome: 3
Canonical length: 271 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable signaling receptor activity. Predicted to be involved in regulation of neuroinflammatory response. Predicted to be located in cell surface and membrane. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

271 residues, UniProt reviewed canonical sequence.

>Q6Q8B3|CD200R1L
     1  MSAPRLLISI IIMVSASSSS CMGGKQMTQN YSTIFAEGNI SQPVLMDINA VLCCPPIALR
    61  NLIIITWEII LRGQPSCTKA YKKETNETKE TNCTVERITW VSRPDQNSDL QIRPVDTTHD
   121  GYYRGIVVTP DGNFHRGYHL QVLVTPEVNL FQSRNITAVC KAVTGKPAAQ ISWIPEGSIL
   181  ATKQEYWGNG TVTVKSTCPW EGHKSTVTCH VSHLTGNKSL SVKLNSGLRT SGSPALSLLI
   241  ILYVKLSLFV VILVTTGFVF FQRINHVRKV L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD200R1L can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 2.6 nTPM

Expression across tissuesHPA

Tissue

testis: 2.6 nTPM
adipose tissue: 0 nTPM
adrenal gland: 0 nTPM
amygdala: 0 nTPM
appendix: 0 nTPM
basal ganglia: 0 nTPM

Single-cell type

late spermatids: 86 nCPM
late primary spermatocytes: 29 nCPM
early spermatids: 20 nCPM
epicardial cells: 2.3 nCPM
endometrial ciliated cells: 1.4 nCPM
gastric progenitor cells: 1.3 nCPM

Immune cell

basophil: 85 nTPM
eosinophil: 0.2 nTPM
myeloid DC: 0.1 nTPM
neutrophil: 0.1 nTPM
T-reg: 0.1 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 0.1 nTPM
amygdala: 0 nTPM
basal ganglia: 0 nTPM
cerebellum: 0 nTPM
choroid plexus: 0 nTPM
hippocampal formation: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.94
gnomAD pLI: 0
gnomAD missense Z: -0.41
DepMap mean gene effect: -0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD200R1L as an antibody target. Whether an autoantibody or antibody against CD200R1L could matter depends on whether native CD200R1L is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD200R1L is annotated at the cell surface, where native CD200R1L is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD200R1L as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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