Seroatlas · Human Serome Atlas

CD200R1

Cell surface glycoprotein CD200 receptor 1

Also known as: CD200R, HCRTR2, MO2R1_HUMAN, MOX2R, OX2R

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8TD46
Gene: CD200R1
Ensembl: ENSG00000163606
Chromosome: 3
Canonical length: 348 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Plasma membrane
Secretome location: Intracellular and membrane

OverviewNCBI Gene

This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

348 residues, UniProt reviewed canonical sequence.

>Q8TD46|CD200R1
     1  MLCPWRTANL GLLLILTIFL VAEAEGAAQP NNSLMLQTSK ENHALASSSL CMDEKQITQN
    61  YSKVLAEVNT SWPVKMATNA VLCCPPIALR NLIIITWEII LRGQPSCTKA YKKETNETKE
   121  TNCTDERITW VSRPDQNSDL QIRTVAITHD GYYRCIMVTP DGNFHRGYHL QVLVTPEVTL
   181  FQNRNRTAVC KAVAGKPAAH ISWIPEGDCA TKQEYWSNGT VTVKSTCHWE VHNVSTVTCH
   241  VSHLTGNKSL YIELLPVPGA KKSAKLYIPY IILTIIILTI VGFIWLLKVN GCRKYKLNKT
   301  ESTPVVEEDE MQPYASYTEK NNPLYDTTNK VKASEALQSE VDTDLHTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD200R1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 7.5 nTPM

Expression across tissuesHPA

Tissue

spleen: 7.5 nTPM
placenta: 5 nTPM
tonsil: 4.3 nTPM
lymph node: 4.1 nTPM
esophagus: 3.6 nTPM
thymus: 3.1 nTPM

Single-cell type

hofbauer cells: 84 nCPM
neutrophil progenitors: 79 nCPM
cdc: 67 nCPM
platelets: 43 nCPM
mast cells: 35 nCPM
macrophages: 34 nCPM

Immune cell

basophil: 236 nTPM
eosinophil: 54 nTPM
myeloid DC: 23 nTPM
memory CD4 T-cell: 14 nTPM
naive CD4 T-cell: 14 nTPM
memory B-cell: 10 nTPM

Brain region

choroid plexus: 1.5 nTPM
cerebral cortex: 1.2 nTPM
basal ganglia: 0.8 nTPM
pons: 0.7 nTPM
amygdala: 0.6 nTPM
medulla oblongata: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
gnomAD missense Z: 0.7
DepMap mean gene effect: -0.03
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD200R1 as an antibody target. Whether an autoantibody or antibody against CD200R1 could matter depends on whether native CD200R1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD200R1 is annotated at the cell surface, where native CD200R1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD200R1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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