Seroatlas · Human Serome Atlas

CD200

OX-2 membrane glycoprotein

Also known as: MOX1, MOX2, MRC, OX-2, OX2G_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P41217
Gene
CD200
Ensembl
ENSG00000091972
Chromosome
3
Canonical length
278 aa
Protein class
CD markers, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]

Canonical amino-acid sequenceUniProt

278 residues, UniProt reviewed canonical sequence.

>P41217|CD200
     1  MERLVIRMPF SHLSTYSLVW VMAAVVLCTA QVQVVTQDER EQLYTPASLK CSLQNAQEAL
    61  IVTWQKKKAV SPENMVTFSE NHGVVIQPAY KDKINITQLG LQNSTITFWN ITLEDEGCYM
   121  CLFNTFGFGK ISGTACLTVY VQPIVSLHYK FSEDHLNITC SATARPAPMV FWKVPRSGIE
   181  NSTVTLSHPN GTTSVTSILH IKDPKNQVGK EVICQVLHLG TVTDFKQTVN KGYWFSVPLL
   241  LSIVSLVILL VLISILLYWK RHRNQDRGEL SQGVQKMT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD200 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.37
Highest tissue expression
64 nTPM

Expression across tissuesHPA

Tissue

  • hypothalamus: 64 nTPM
  • cerebral cortex: 49 nTPM
  • basal ganglia: 43 nTPM
  • blood vessel: 33 nTPM
  • cerebellum: 31 nTPM
  • endometrium: 27 nTPM

Single-cell type

  • epicardial cells: 262 nCPM
  • epididymal basal cells: 215 nCPM
  • mesothelial cells: 146 nCPM
  • endometrial glandular cells: 103 nCPM
  • other brain neurons: 102 nCPM
  • lymphatic endothelial cells: 97 nCPM

Immune cell

  • naive B-cell: 84 nTPM
  • memory B-cell: 31 nTPM
  • basophil: 3.6 nTPM
  • MAIT T-cell: 3.5 nTPM
  • total PBMC: 3.4 nTPM
  • plasmacytoid DC: 2.7 nTPM

Brain region

  • hypothalamus: 98 nTPM
  • basal ganglia: 68 nTPM
  • cerebral cortex: 68 nTPM
  • pons: 51 nTPM
  • white matter: 48 nTPM
  • midbrain: 46 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.56
gnomAD pLI
0.41
gnomAD missense Z
0.66
DepMap mean gene effect
0.08
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD200 as an antibody target. Whether an autoantibody or antibody against CD200 could matter depends on whether native CD200 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD200 is annotated at the cell surface, where native CD200 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD200 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD200. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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