Seroatlas · Human Serome Atlas

CD164L2

CD164 sialomucin-like 2 protein

Also known as: C16L2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q6UWJ8
Gene
CD164L2
Ensembl
ENSG00000174950
Chromosome
1
Canonical length
174 aa
Protein class
Predicted membrane proteins
Subcellular location
Plasma membrane,Cytosol

OverviewNCBI Gene

Predicted to be located in membrane. Predicted to be active in cytoplasmic vesicle. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

174 residues, UniProt reviewed canonical sequence.

>Q6UWJ8|CD164L2
     1  MEAPGPRALR TALCGGCCCL LLCAQLAVAG KGARGFGRGA LIRLNIWPAV QGACKQLEVC
    61  EHCVEGDGAR NLSSCVWEQC RPEEPGHCVA QSEVVKEGCS IYNRSEACPA AHHHPTYEPK
   121  TVTTGSPPVP EAHSPGFDGA SFIGGVVLVL SLQAVAFFVL HFLKAKDSTY QTLI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD164L2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
28 nTPM

Expression across tissuesHPA

Tissue

  • fallopian tube: 28 nTPM
  • esophagus: 19 nTPM
  • salivary gland: 13 nTPM
  • skin: 11 nTPM
  • vagina: 8.9 nTPM
  • cervix: 7.4 nTPM

Single-cell type

  • fallopian tube ciliated cells: 197 nCPM
  • respiratory ciliated cells: 154 nCPM
  • epididymal efferent duct ciliated cells: 112 nCPM
  • endometrial ciliated cells: 62 nCPM
  • esophageal apical cells: 55 nCPM
  • esophageal suprabasal cells: 47 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • medulla oblongata: 4.2 nTPM
  • midbrain: 2.9 nTPM
  • choroid plexus: 2 nTPM
  • spinal cord: 1.7 nTPM
  • cerebral cortex: 0.8 nTPM
  • hippocampal formation: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.58
gnomAD pLI
0
gnomAD missense Z
0.2
DepMap mean gene effect
0.07
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD164L2 as an antibody target. Whether an autoantibody or antibody against CD164L2 could matter depends on whether native CD164L2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD164L2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CD164L2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD164L2. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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