Seroatlas · Human Serome Atlas

CD164

Sialomucin core protein 24

Also known as: DFNA66, MGC-24, MUC-24, MUC24_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q04900
Gene
CD164
Ensembl
ENSG00000135535
Chromosome
6
Canonical length
197 aa
Protein class
CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Secretome location
Intracellular and membrane
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a transmembrane sialomucin and cell adhesion molecule that regulates the proliferation, adhesion and migration of hematopoietic progenitor cells. The encoded protein also interacts with the C-X-C chemokine receptor type 4 and may regulate muscle development. Elevated expression of this gene has been observed in human patients with Sezary syndrome, a type of blood cancer, and a mutation in this gene may be associated with impaired hearing. [provided by RefSeq, Oct 2016]

Canonical amino-acid sequenceUniProt

197 residues, UniProt reviewed canonical sequence.

>Q04900|CD164
     1  MSRLSRSLLW AATCLGVLCV LSADKNTTQH PNVTTLAPIS NVTSAPVTSL PLVTTPAPET
    61  CEGRNSCVSC FNVSVVNTTC FWIECKDESY CSHNSTVSDC QVGNTTDFCS VSTATPVPTA
   121  NSTAKPTVQP SPSTTSKTVT TSGTTNNTVT PTSQPVRKST FDAASFIGGI VLVLGVQAVI
   181  FFLYKFCKSK ERNYHTL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD164 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.58
Highest tissue expression
337 nTPM

Expression across tissuesHPA

Tissue

  • thyroid gland: 337 nTPM
  • salivary gland: 286 nTPM
  • kidney: 278 nTPM
  • small intestine: 262 nTPM
  • stomach: 258 nTPM
  • rectum: 254 nTPM

Single-cell type

  • syncytiotrophoblasts: 886 nCPM
  • parietal cells: 732 nCPM
  • kupffer cells: 537 nCPM
  • extravillous trophoblasts: 537 nCPM
  • neutrophil progenitors: 535 nCPM
  • retinal pigment epithelial cells: 529 nCPM

Immune cell

  • total PBMC: 413 nTPM
  • basophil: 350 nTPM
  • NK-cell: 256 nTPM
  • plasmacytoid DC: 214 nTPM
  • intermediate monocyte: 199 nTPM
  • non-classical monocyte: 199 nTPM

Brain region

  • white matter: 104 nTPM
  • choroid plexus: 100 nTPM
  • medulla oblongata: 94 nTPM
  • hypothalamus: 77 nTPM
  • cerebellum: 75 nTPM
  • midbrain: 73 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CD164.

Disease | AllUniProt

Conditions CD164 is implicated in, by any mechanism.

  • Deafness, autosomal dominant, 66 (DFNA66) MIM:616969

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.61
gnomAD pLI
0.49
gnomAD missense Z
-0.26
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD164 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD164 as an antibody target. Whether an autoantibody or antibody against CD164 could matter depends on whether native CD164 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD164 is annotated at the cell surface, where native CD164 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD164 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD164. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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