Seroatlas · Human Serome Atlas

CD163L1

Scavenger receptor cysteine-rich type 1 protein M160

Also known as: C163B_HUMAN, CD163B, M160, SCARI2, WC1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NR16
Gene
CD163L1
Ensembl
ENSG00000177675
Chromosome
12
Canonical length
1453 aa
Protein class
CD markers, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Centrosome,Cytosol
Secretome location
Intracellular and membrane

OverviewNCBI Gene

This gene encodes a member of the scavenger receptor cysteine-rich (SRCR) superfamily. Members of this family are secreted or membrane-anchored proteins mainly found in cells associated with the immune system. The SRCR family is defined by a 100-110 amino acid SRCR domain, which may mediate protein-protein interaction and ligand binding. The encoded protein contains twelve SRCR domains, a transmembrane region and a cytoplasmic domain. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

1453 residues, UniProt reviewed canonical sequence.

>Q9NR16|CD163L1
     1  MMLPQNSWHI DFGRCCCHQN LFSAVVTCIL LLNSCFLISS FNGTDLELRL VNGDGPCSGT
    61  VEVKFQGQWG TVCDDGWNTT ASTVVCKQLG CPFSFAMFRF GQAVTRHGKI WLDDVSCYGN
   121  ESALWECQHR EWGSHNCYHG EDVGVNCYGE ANLGLRLVDG NNSCSGRVEV KFQERWGTIC
   181  DDGWNLNTAA VVCRQLGCPS SFISSGVVNS PAVLRPIWLD DILCQGNELA LWNCRHRGWG
   241  NHDCSHNEDV TLTCYDSSDL ELRLVGGTNR CMGRVELKIQ GRWGTVCHHK WNNAAADVVC
   301  KQLGCGTALH FAGLPHLQSG SDVVWLDGVS CSGNESFLWD CRHSGTVNFD CLHQNDVSVI
   361  CSDGADLELR LADGSNNCSG RVEVRIHEQW WTICDQNWKN EQALVVCKQL GCPFSVFGSR
   421  RAKPSNEARD IWINSISCTG NESALWDCTY DGKAKRTCFR RSDAGVICSD KADLDLRLVG
   481  AHSPCYGRLE VKYQGEWGTV CHDRWSTRNA AVVCKQLGCG KPLHVFGMTY FKEASGPIWL
   541  DDVSCIGNES NIWDCEHSGW GKHNCVHRED VIVTCSGDAT WGLRLVGGSN RCSGRLEVYF
   601  QGRWGTVCDD GWNSKAAAVV CSQLDCPSSI IGMGLGNAST GYGKIWLDDV SCDGDESDLW
   661  SCRNSGWGNN DCSHSEDVGV ICSDASDMEL RLVGGSSRCA GKVEVNVQGA VGILCANGWG
   721  MNIAEVVCRQ LECGSAIRVS REPHFTERTL HILMSNSGCT GGEASLWDCI RWEWKQTACH
   781  LNMEASLICS AHRQPRLVGA DMPCSGRVEV KHADTWRSVC DSDFSLHAAN VLCRELNCGD
   841  AISLSVGDHF GKGNGLTWAE KFQCEGSETH LALCPIVQHP EDTCIHSREV GVVCSRYTDV
   901  RLVNGKSQCD GQVEINVLGH WGSLCDTHWD PEDARVLCRQ LSCGTALSTT GGKYIGERSV
   961  RVWGHRFHCL GNESLLDNCQ MTVLGAPPCI HGNTVSVICT GSLTQPLFPC LANVSDPYLS
  1021  AVPEGSALIC LEDKRLRLVD GDSRCAGRVE IYHDGFWGTI CDDGWDLSDA HVVCQKLGCG
  1081  VAFNATVSAH FGEGSGPIWL DDLNCTGMES HLWQCPSRGW GQHDCRHKED AGVICSEFTA
  1141  LRLYSETETE SCAGRLEVFY NGTWGSVGRR NITTAIAGIV CRQLGCGENG VVSLAPLSKT
  1201  GSGFMWVDDI QCPKTHISIW QCLSAPWERR ISSPAEETWI TCEDRIRVRG GDTECSGRVE
  1261  IWHAGSWGTV CDDSWDLAEA EVVCQQLGCG SALAALRDAS FGQGTGTIWL DDMRCKGNES
  1321  FLWDCHAKPW GQSDCGHKED AGVRCSGQSL KSLNASSGHL ALILSSIFGL LLLVLFILFL
  1381  TWCRVQKQKH LPLRVSTRRR GSLEENLFHE METCLKREDP HGTRTSDDTP NHGCEDASDT
  1441  SLLGVLPASE ATK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD163L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.31
Highest tissue expression
30 nTPM

Expression across tissuesHPA

Tissue

  • spleen: 30 nTPM
  • rectum: 21 nTPM
  • small intestine: 17 nTPM
  • colon: 14 nTPM
  • placenta: 9.9 nTPM
  • duodenum: 8 nTPM

Single-cell type

  • macrophages: 218 nCPM
  • neutrophils: 164 nCPM
  • kupffer cells: 153 nCPM
  • hofbauer cells: 136 nCPM
  • breast lactating cells: 83 nCPM
  • retinal ganglion cells: 70 nCPM

Immune cell

  • intermediate monocyte: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 8.8 nTPM
  • pons: 4.5 nTPM
  • cerebral cortex: 3.8 nTPM
  • choroid plexus: 3.6 nTPM
  • midbrain: 3.5 nTPM
  • spinal cord: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.86
gnomAD pLI
0
gnomAD missense Z
1.23
DepMap mean gene effect
0.15
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD163L1 as an antibody target. Whether an autoantibody or antibody against CD163L1 could matter depends on whether native CD163L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD163L1 is annotated at the cell surface, where native CD163L1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD163L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD163L1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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