Seroatlas · Human Serome Atlas

CCT8L1P

Putative T-complex protein 1 subunit theta-like 1

Also known as: TCPQL_HUMAN

Cross-references: UniProt · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NM43
Gene: CCT8L1P
Canonical length: 557 aa

OverviewNCBI Gene

No narrative summary is available for CCT8L1P in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

557 residues, UniProt reviewed canonical sequence.

>A6NM43|CCT8L1P
     1  MDSTVPSALE LPQRLALNPR ESPRSPEEEE PHLLSSLAAV QTLANVIRPC YGPHGRQKFL
    61  VTMKGETVCT GCATAILRAL ELEHPAAWLL REAAQTQAEN SGDGTAFVVL LTEALLEQAE
   121  QLLKFGLPRP QLREAYATAT AEVLATLPSL AIQSLGPLED PSWALHSVMN THTLPPMNHL
   181  TKLVAHACWA IKELDGSFKP ERVGVCTLHG GTLEDSCLLQ GLAISGKLCG QMAAVLSGAR
   241  VALFACPFGP AHPNAPATAC LSSPADLAQF SKGSDQLLEK QVGQLAAAGI NVAVVLGEVD
   301  EETLTLADKY GIVVIQARSR MEIIYLSEVL DTPLLPRLLP PQRPGKCQRV YRQELGDGLA
   361  VVFEWECTGT PALTVVLRGA TTQGLRSAEQ AVYHSIDAYF QPCQDPRLIP GAGATEMALA
   421  KMLSDKGSRL EGPNGPAFLA FARALKYLPK TLAENAGLAV SDVVAEMSGV HQGGNLLMGV
   481  GAEGIINVAQ EGVWDTLIVK AQGFRAVAEV VLQLVTVDEI VVAKKSPTHQ QIWNPDSKKT
   541  KKRPPPVEKK KILGMNN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCT8L1P can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.3

OntologyGO

Biological processes

protein folding

Molecular functions

Cellular components

chaperonin-containing T-complex

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCT8L1P as an antibody target. Whether an autoantibody or antibody against CCT8L1P could matter depends on whether native CCT8L1P is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCT8L1P is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCT8L1P as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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