Seroatlas · Human Serome Atlas

CCSAP

Centriole, cilia and spindle-associated protein

Also known as: C1orf96, CCSAP_HUMAN, CSAP, FLJ41471

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6IQ19
Gene: CCSAP
Ensembl: ENSG00000154429
Chromosome: 1
Canonical length: 270 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Enables microtubule binding activity. Involved in mitotic spindle microtubule depolymerization and regulation of mitotic spindle assembly. Located in axon; ciliary transition zone; and cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

270 residues, UniProt reviewed canonical sequence.

>Q6IQ19|CCSAP
     1  MSPGSGVKSE YMKRYQEPRW EEYGPCYREL LHYRLGRRLL EQAHAPWLWD DWGPAGSSED
    61  SASSESSGAG GPAPRCAPPS PPPPVEPATQ EEAERRARGA PEEQDAEAGD AEAEDAEDAA
   121  LPALPVKDVE DKPEQQTRTR ETDKSPTSTE PRQQPSALFA RGNRKAVKSP QRSSSKIKEN
   181  KHPFALYGWG EKQTDTGSQK THNVCASAPV HEIHESALRA KNRRQVEKRK LVAQRQRAHS
   241  VDVEKNRKMK ASSSENPWMT EYMRCYSARA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCSAP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.64
Highest tissue expression: 31 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 31 nTPM
cerebellum: 30 nTPM
retina: 24 nTPM
basal ganglia: 16 nTPM
hippocampal formation: 14 nTPM
amygdala: 14 nTPM

Single-cell type

syncytiotrophoblasts: 151 nCPM
retinal bipolar cells: 89 nCPM
brain inhibitory neurons: 60 nCPM
monocyte progenitors: 58 nCPM
extravillous trophoblasts: 57 nCPM
somatotrophs: 56 nCPM

Immune cell

basophil: 3.7 nTPM
non-classical monocyte: 1.4 nTPM
eosinophil: 1.3 nTPM
intermediate monocyte: 1.2 nTPM
neutrophil: 0.9 nTPM
MAIT T-cell: 0.7 nTPM

Brain region

cerebral cortex: 57 nTPM
cerebellum: 55 nTPM
hippocampal formation: 47 nTPM
white matter: 46 nTPM
basal ganglia: 45 nTPM
amygdala: 39 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0.1
gnomAD missense Z: 1.46
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

cell division
regulation of embryonic development
regulation of mitotic spindle assembly
mitotic spindle microtubule depolymerization

Molecular functions

microtubule binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Centriole, cilia and spindle-associated protein
Centriole, cilia and spindle-associated

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCSAP as an antibody target. Whether an autoantibody or antibody against CCSAP could matter depends on whether native CCSAP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCSAP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCSAP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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