Seroatlas · Human Serome Atlas

CCRL2

C-C chemokine receptor-like 2

Also known as: ACKR5, CCRL2_HUMAN, CKRX, CRAM-A, CRAM-B, HCR

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00421
Gene: CCRL2
Ensembl: ENSG00000121797
Chromosome: 3
Canonical length: 344 aa
Protein class: G-protein coupled receptors, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a chemokine receptor like protein, which is predicted to be a seven transmembrane protein and most closely related to CCR1. Chemokines and their receptors mediated signal transduction are critical for the recruitment of effector immune cells to the site of inflammation. This gene is expressed at high levels in primary neutrophils and primary monocytes, and is further upregulated on neutrophil activation and during monocyte to macrophage differentiation. The function of this gene is unknown. This gene is mapped to the region where the chemokine receptor gene cluster is located. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>O00421|CCRL2
     1  MANYTLAPED EYDVLIEGEL ESDEAEQCDK YDAQALSAQL VPSLCSAVFV IGVLDNLLVV
    61  LILVKYKGLK RVENIYLLNL AVSNLCFLLT LPFWAHAGGD PMCKILIGLY FVGLYSETFF
   121  NCLLTVQRYL VFLHKGNFFS ARRRVPCGII TSVLAWVTAI LATLPEFVVY KPQMEDQKYK
   181  CAFSRTPFLP ADETFWKHFL TLKMNISVLV LPLFIFTFLY VQMRKTLRFR EQRYSLFKLV
   241  FAIMVVFLLM WAPYNIAFFL STFKEHFSLS DCKSSYNLDK SVHITKLIAT THCCINPLLY
   301  AFLDGTFSKY LCRCFHLRSN TPLQPRGQSA QGTSREEPDH STEV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCRL2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

lung: 12 nTPM
adipose tissue: 12 nTPM
small intestine: 11 nTPM
duodenum: 11 nTPM
appendix: 11 nTPM
colon: 11 nTPM

Single-cell type

monocytes: 116 nCPM
neutrophils: 66 nCPM
hofbauer cells: 39 nCPM
macrophages: 36 nCPM
cdc: 22 nCPM
goblet cells: 20 nCPM

Immune cell

intermediate monocyte: 22 nTPM
classical monocyte: 15 nTPM
non-classical monocyte: 10 nTPM
myeloid DC: 9.9 nTPM
basophil: 8.8 nTPM
NK-cell: 6.7 nTPM

Brain region

cerebral cortex: 4 nTPM
white matter: 3.4 nTPM
pons: 3.3 nTPM
thalamus: 2.8 nTPM
medulla oblongata: 2.5 nTPM
spinal cord: 2.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCRL2.

Disease | ImmuneIEDB

Conditions an epitope on CCRL2 was assayed in.

colonic benign neoplasm T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0.37
gnomAD missense Z: -0.41
DepMap mean gene effect: 0.05
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCRL2 as an antibody target. Whether an autoantibody or antibody against CCRL2 could matter depends on whether native CCRL2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCRL2 is annotated at the cell surface, where native CCRL2 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CCRL2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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