Seroatlas · Human Serome Atlas

CCR8

C-C chemokine receptor type 8

Also known as: CCR8_HUMAN, CDw198, CKR-L1, CMKBR8, CMKBRL2, CY6, GPR-CY6, TER1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51685
Gene
CCR8
Ensembl
ENSG00000179934
Chromosome
3
Canonical length
355 aa
Protein class
CD markers, G-protein coupled receptors, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptors are important for the migration of various cell types into the inflammatory sites. This receptor protein preferentially expresses in the thymus. I-309, thymus activation-regulated cytokine (TARC) and macrophage inflammatory protein-1 beta (MIP-1 beta) have been identified as ligands of this receptor. Studies of this receptor and its ligands suggested its role in regulation of monocyte chemotaxis and thymic cell apoptosis. More specifically, this receptor may contribute to the proper positioning of activated T cells within the antigenic challenge sites and specialized areas of lymphoid tissues. This gene is located at the chemokine receptor gene cluster region. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

355 residues, UniProt reviewed canonical sequence.

>P51685|CCR8
     1  MDYTLDLSVT TVTDYYYPDI FSSPCDAELI QTNGKLLLAV FYCLLFVFSL LGNSLVILVL
    61  VVCKKLRSIT DVYLLNLALS DLLFVFSFPF QTYYLLDQWV FGTVMCKVVS GFYYIGFYSS
   121  MFFITLMSVD RYLAVVHAVY ALKVRTIRMG TTLCLAVWLT AIMATIPLLV FYQVASEDGV
   181  LQCYSFYNQQ TLKWKIFTNF KMNILGLLIP FTIFMFCYIK ILHQLKRCQN HNKTKAIRLV
   241  LIVVIASLLF WVPFNVVLFL TSLHSMHILD GCSISQQLTY ATHVTEIISF THCCVNPVIY
   301  AFVGEKFKKH LSEIFQKSCS QIFNYLGRQM PRESCEKSSS CQQHSSRSSS VDYIL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCR8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
7.2 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 7.2 nTPM
  • urinary bladder: 1.2 nTPM
  • appendix: 0.9 nTPM
  • gallbladder: 0.6 nTPM
  • lymph node: 0.6 nTPM
  • tonsil: 0.6 nTPM

Single-cell type

  • cone photoreceptor cells: 4.1 nCPM
  • t-cells: 3.2 nCPM
  • epicardial cells: 2.3 nCPM
  • suprabasal keratinocytes: 0.5 nCPM
  • foveolar cells: 0.4 nCPM
  • innate lymphoid cells: 0.4 nCPM

Immune cell

  • T-reg: 26 nTPM
  • memory CD4 T-cell: 4.6 nTPM
  • memory CD8 T-cell: 2 nTPM
  • NK-cell: 0.8 nTPM
  • total PBMC: 0.8 nTPM
  • naive CD4 T-cell: 0.3 nTPM

Brain region

  • choroid plexus: 0.3 nTPM
  • medulla oblongata: 0.3 nTPM
  • basal ganglia: 0.2 nTPM
  • cerebral cortex: 0.2 nTPM
  • hippocampal formation: 0.2 nTPM
  • hypothalamus: 0.2 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.34
gnomAD pLI
0.01
gnomAD missense Z
0.24
DepMap mean gene effect
0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCR8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCR8 as an antibody target. Whether an autoantibody or antibody against CCR8 could matter depends on whether native CCR8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCR8 is annotated at the cell surface, where native CCR8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CCR8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCR8. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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