Seroatlas · Human Serome Atlas

CCR7

C-C chemokine receptor type 7

Also known as: BLR2, CCR7_HUMAN, CD197, CDw197, CMKBR7, EBI1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P32248
Gene
CCR7
Ensembl
ENSG00000126353
Chromosome
17
Canonical length
378 aa
Protein class
Cancer-related genes, CD markers, G-protein coupled receptors, Predicted membrane proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

378 residues, UniProt reviewed canonical sequence.

>P32248|CCR7
     1  MDLGKPMKSV LVVALLVIFQ VCLCQDEVTD DYIGDNTTVD YTLFESLCSK KDVRNFKAWF
    61  LPIMYSIICF VGLLGNGLVV LTYIYFKRLK TMTDTYLLNL AVADILFLLT LPFWAYSAAK
   121  SWVFGVHFCK LIFAIYKMSF FSGMLLLLCI SIDRYVAIVQ AVSAHRHRAR VLLISKLSCV
   181  GIWILATVLS IPELLYSDLQ RSSSEQAMRC SLITEHVEAF ITIQVAQMVI GFLVPLLAMS
   241  FCYLVIIRTL LQARNFERNK AIKVIIAVVV VFIVFQLPYN GVVLAQTVAN FNITSSTCEL
   301  SKQLNIAYDV TYSLACVRCC VNPFLYAFIG VKFRNDLFKL FKDLGCLSQE QLRQWSSCRH
   361  IRRSSMSVEA ETTTTFSP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCR7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
79 nTPM

Expression across tissuesHPA

Tissue

  • lymph node: 79 nTPM
  • tonsil: 78 nTPM
  • appendix: 63 nTPM
  • thymus: 55 nTPM
  • spleen: 27 nTPM
  • small intestine: 20 nTPM

Single-cell type

  • syncytiotrophoblasts: 576 nCPM
  • cdc: 228 nCPM
  • cytotrophoblasts: 165 nCPM
  • migrating cytotrophoblasts: 143 nCPM
  • b-cells: 116 nCPM
  • t-cells: 47 nCPM

Immune cell

  • naive CD4 T-cell: 4,612 nTPM
  • total PBMC: 2,492 nTPM
  • naive CD8 T-cell: 2,470 nTPM
  • naive B-cell: 1,127 nTPM
  • memory CD4 T-cell: 999 nTPM
  • NK-cell: 973 nTPM

Brain region

  • white matter: 2.5 nTPM
  • choroid plexus: 2.1 nTPM
  • cerebral cortex: 1.6 nTPM
  • basal ganglia: 1.5 nTPM
  • pons: 1.4 nTPM
  • thalamus: 1.4 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCR7.

Disease | ImmuneIEDB

Conditions an epitope on CCR7 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.78
gnomAD pLI
0.06
gnomAD missense Z
2.18
DepMap mean gene effect
-0.12
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCR7 as an antibody target. Whether an autoantibody or antibody against CCR7 could matter depends on whether native CCR7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCR7 is annotated at the cell surface, where native CCR7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CCR7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCR7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...