Seroatlas · Human Serome Atlas

CCR6

C-C chemokine receptor type 6

Also known as: BN-1, CCR6_HUMAN, CD196, CKR-L3, CMKBR6, DCR2, DRY-6, GPR-CY4, GPR29, STRL22

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51684
Gene
CCR6
Ensembl
ENSG00000112486
Chromosome
6
Canonical length
374 aa
Protein class
CD markers, G-protein coupled receptors, Human disease related genes, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

374 residues, UniProt reviewed canonical sequence.

>P51684|CCR6
     1  MSGESMNFSD VFDSSEDYFV SVNTSYYSVD SEMLLCSLQE VRQFSRLFVP IAYSLICVFG
    61  LLGNILVVIT FAFYKKARSM TDVYLLNMAI ADILFVLTLP FWAVSHATGA WVFSNATCKL
   121  LKGIYAINFN CGMLLLTCIS MDRYIAIVQA TKSFRLRSRT LPRSKIICLV VWGLSVIISS
   181  STFVFNQKYN TQGSDVCEPK YQTVSEPIRW KLLMLGLELL FGFFIPLMFM IFCYTFIVKT
   241  LVQAQNSKRH KAIRVIIAVV LVFLACQIPH NMVLLVTAAN LGKMNRSCQS EKLIGYTKTV
   301  TEVLAFLHCC LNPVLYAFIG QKFRNYFLKI LKDLWCVRRK YKSSGFSCAG RYSENISRQT
   361  SETADNDNAS SFTM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCR6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
32 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 32 nTPM
  • lymph node: 16 nTPM
  • spleen: 11 nTPM
  • appendix: 8.6 nTPM
  • small intestine: 6.2 nTPM
  • urinary bladder: 3.4 nTPM

Single-cell type

  • ependymal cells: 6.6 nCPM
  • b-cells: 5.8 nCPM
  • t-cells: 3 nCPM
  • proximal tubule cells: 2.6 nCPM
  • renal collecting duct principal cells: 2.4 nCPM
  • brain inhibitory neurons: 2.3 nCPM

Immune cell

  • naive B-cell: 73 nTPM
  • MAIT T-cell: 70 nTPM
  • memory B-cell: 64 nTPM
  • T-reg: 52 nTPM
  • memory CD4 T-cell: 27 nTPM
  • myeloid DC: 13 nTPM

Brain region

  • cerebral cortex: 0.8 nTPM
  • hippocampal formation: 0.7 nTPM
  • amygdala: 0.6 nTPM
  • basal ganglia: 0.6 nTPM
  • pons: 0.6 nTPM
  • hypothalamus: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.04
gnomAD pLI
0.01
gnomAD missense Z
2.13
DepMap mean gene effect
0.05
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCR6 as an antibody target. Whether an autoantibody or antibody against CCR6 could matter depends on whether native CCR6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCR6 is annotated at the cell surface, where native CCR6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CCR6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCR6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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