Seroatlas · Human Serome Atlas

CCR4

C-C chemokine receptor type 4

Also known as: CC-CKR-4, CCR4_HUMAN, CD194, ChemR13, CKR4, CMKBR4, k5-5

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P51679
Gene: CCR4
Ensembl: ENSG00000183813
Chromosome: 3
Canonical length: 360 aa
Protein class: CD markers, FDA approved drug targets, G-protein coupled receptors, Predicted membrane proteins
Subcellular location: Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to the G-protein-coupled receptor family . It is a receptor for the CC chemokine - MIP-1, RANTES, TARC and MCP-1. Chemokines are a group of small polypeptide, structurally related molecules that regulate cell trafficking of various types of leukocytes. The chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>P51679|CCR4
     1  MNPTDIADTT LDESIYSNYY LYESIPKPCT KEGIKAFGEL FLPPLYSLVF VFGLLGNSVV
    61  VLVLFKYKRL RSMTDVYLLN LAISDLLFVF SLPFWGYYAA DQWVFGLGLC KMISWMYLVG
   121  FYSGIFFVML MSIDRYLAIV HAVFSLRART LTYGVITSLA TWSVAVFASL PGFLFSTCYT
   181  ERNHTYCKTK YSLNSTTWKV LSSLEINILG LVIPLGIMLF CYSMIIRTLQ HCKNEKKNKA
   241  VKMIFAVVVL FLGFWTPYNI VLFLETLVEL EVLQDCTFER YLDYAIQATE TLAFVHCCLN
   301  PIIYFFLGEK FRKYILQLFK TCRGLFVLCQ YCGLLQIYSA DTPSSSYTQS TMDHDLHDAL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCR4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

thymus: 12 nTPM
appendix: 8.1 nTPM
tonsil: 7.5 nTPM
lymph node: 6.5 nTPM
urinary bladder: 5.1 nTPM
gallbladder: 3.1 nTPM

Single-cell type

platelets: 33 nCPM
t-cells: 18 nCPM
innate lymphoid cells: 14 nCPM
differentiating spermatogonia: 2.7 nCPM
mast cells: 1.4 nCPM
foveolar cells: 0.6 nCPM

Immune cell

T-reg: 61 nTPM
memory CD4 T-cell: 12 nTPM
memory CD8 T-cell: 3.4 nTPM
total PBMC: 1.7 nTPM
basophil: 1.4 nTPM
neutrophil: 1 nTPM

Brain region

white matter: 5.2 nTPM
cerebellum: 5.1 nTPM
cerebral cortex: 4.9 nTPM
hippocampal formation: 4.6 nTPM
hypothalamus: 4.4 nTPM
pons: 4.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0.07
gnomAD missense Z: 0.75
DepMap mean gene effect: 0.02
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCR4 as an antibody target. Whether an autoantibody or antibody against CCR4 could matter depends on whether native CCR4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCR4 is annotated at the cell surface, where native CCR4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CCR4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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