Seroatlas · Human Serome Atlas

CCR3

C-C chemokine receptor type 3

Also known as: CC-CKR-3, CCR3_HUMAN, CD193, CKR3, CMKBR3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P51677
Gene
CCR3
Ensembl
ENSG00000183625
Chromosome
3
Canonical length
355 aa
Protein class
CD markers, G-protein coupled receptors, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane
Quaternary structure
Homooligomer

OverviewNCBI Gene

The protein encoded by this gene is a receptor for C-C type chemokines. It belongs to family 1 of the G protein-coupled receptors. This receptor binds and responds to a variety of chemokines, including eotaxin (CCL11), eotaxin-3 (CCL26), MCP-3 (CCL7), MCP-4 (CCL13), and RANTES (CCL5). It is highly expressed in eosinophils and basophils, and is also detected in TH1 and TH2 cells, as well as in airway epithelial cells. This receptor may contribute to the accumulation and activation of eosinophils and other inflammatory cells in the allergic airway. It is also known to be an entry co-receptor for HIV-1. This gene and seven other chemokine receptor genes form a chemokine receptor gene cluster on the chromosomal region 3p21. Alternatively spliced transcript variants have been described. [provided by RefSeq, Sep 2009]

Canonical amino-acid sequenceUniProt

355 residues, UniProt reviewed canonical sequence.

>P51677|CCR3
     1  MTTSLDTVET FGTTSYYDDV GLLCEKADTR ALMAQFVPPL YSLVFTVGLL GNVVVVMILI
    61  KYRRLRIMTN IYLLNLAISD LLFLVTLPFW IHYVRGHNWV FGHGMCKLLS GFYHTGLYSE
   121  IFFIILLTID RYLAIVHAVF ALRARTVTFG VITSIVTWGL AVLAALPEFI FYETEELFEE
   181  TLCSALYPED TVYSWRHFHT LRMTIFCLVL PLLVMAICYT GIIKTLLRCP SKKKYKAIRL
   241  IFVIMAVFFI FWTPYNVAIL LSSYQSILFG NDCERSKHLD LVMLVTEVIA YSHCCMNPVI
   301  YAFVGERFRK YLRHFFHRHL LMHLGRYIPF LPSEKLERTS SVSPSTAEPE LSIVF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCR3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.33
Highest tissue expression
2.4 nTPM

Expression across tissuesHPA

Tissue

  • small intestine: 2.4 nTPM
  • skeletal muscle: 1.6 nTPM
  • appendix: 1.5 nTPM
  • spleen: 1.4 nTPM
  • duodenum: 1.2 nTPM
  • stomach: 1.1 nTPM

Single-cell type

  • myonuclei: 197 nCPM
  • neutrophils: 178 nCPM
  • migrating cytotrophoblasts: 30 nCPM
  • extravillous trophoblasts: 25 nCPM
  • pdcs: 18 nCPM
  • oocytes: 14 nCPM

Immune cell

  • basophil: 3,400 nTPM
  • eosinophil: 2,516 nTPM
  • neutrophil: 116 nTPM
  • T-reg: 31 nTPM
  • total PBMC: 7.6 nTPM
  • plasmacytoid DC: 3.5 nTPM

Brain region

  • basal ganglia: 0.2 nTPM
  • thalamus: 0.2 nTPM
  • cerebral cortex: 0.1 nTPM
  • choroid plexus: 0.1 nTPM
  • medulla oblongata: 0.1 nTPM
  • spinal cord: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.37
gnomAD pLI
0
gnomAD missense Z
0.1
DepMap mean gene effect
-0.07
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCR3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCR3 as an antibody target. Whether an autoantibody or antibody against CCR3 could matter depends on whether native CCR3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCR3 is annotated at the cell surface, where native CCR3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CCR3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCR3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...