Seroatlas · Human Serome Atlas

CCR10

C-C chemokine receptor type 10

Also known as: CCR10_HUMAN, GPR2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P46092
Gene: CCR10
Ensembl: ENSG00000184451
Chromosome: 17
Canonical length: 362 aa
Protein class: Cancer-related genes, G-protein coupled receptors, Plasma proteins, Predicted membrane proteins
Subcellular location: Endoplasmic reticulum

OverviewNCBI Gene

Chemokines are a group of small (approximately 8 to 14 kD), mostly basic, structurally related molecules that regulate cell trafficking of various types of leukocytes through interactions with a subset of 7-transmembrane, G protein-coupled receptors. Chemokines also play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Chemokines are divided into 2 major subfamilies, CXC and CC, based on the arrangement of the first 2 of the 4 conserved cysteine residues; the 2 cysteines are separated by a single amino acid in CXC chemokines and are adjacent in CC chemokines. CCR10 is the receptor for CCL27 (SCYA27; MIM 604833); CCR10-CCL27 interactions are involved in T cell-mediated skin inflammation (Homey et al., 2002 [PubMed 11821900]).[supplied by OMIM, Mar 2008]

Canonical amino-acid sequenceUniProt

362 residues, UniProt reviewed canonical sequence.

>P46092|CCR10
     1  MGTEATEQVS WGHYSGDEED AYSAEPLPEL CYKADVQAFS RAFQPSVSLT VAALGLAGNG
    61  LVLATHLAAR RAARSPTSAH LLQLALADLL LALTLPFAAA GALQGWSLGS ATCRTISGLY
   121  SASFHAGFLF LACISADRYV AIARALPAGP RPSTPGRAHL VSVIVWLLSL LLALPALLFS
   181  QDGQREGQRR CRLIFPEGLT QTVKGASAVA QVALGFALPL GVMVACYALL GRTLLAARGP
   241  ERRRALRVVV ALVAAFVVLQ LPYSLALLLD TADLLAARER SCPASKRKDV ALLVTSGLAL
   301  ARCGLNPVLY AFLGLRFRQD LRRLLRGGSC PSGPQPRRGC PRRPRLSSCS APTETHSLSW
   361  DN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCR10 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 7
Mean surface accessibility (rSASA): 0.36
Highest tissue expression: 20 nTPM

Expression across tissuesHPA

Tissue

pituitary gland: 20 nTPM
cerebellum: 9.8 nTPM
endometrium: 8.8 nTPM
hypothalamus: 7.2 nTPM
fallopian tube: 7.1 nTPM
cervix: 6.9 nTPM

Single-cell type

plasma cells: 107 nCPM
cardiomyocytes: 81 nCPM
epicardial cells: 61 nCPM
pericytes: 37 nCPM
epididymal principal cells: 30 nCPM
vascular smooth muscle cells: 17 nCPM

Immune cell

T-reg: 73 nTPM
plasmacytoid DC: 25 nTPM
memory CD4 T-cell: 11 nTPM
naive B-cell: 5.9 nTPM
memory CD8 T-cell: 5.4 nTPM
memory B-cell: 5.3 nTPM

Brain region

pons: 20 nTPM
hypothalamus: 19 nTPM
midbrain: 16 nTPM
medulla oblongata: 14 nTPM
cerebral cortex: 13 nTPM
cerebellum: 12 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.36
gnomAD pLI: 0
gnomAD missense Z: 1.89
DepMap mean gene effect: -0.09
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCR10 as an antibody target. Whether an autoantibody or antibody against CCR10 could matter depends on whether native CCR10 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCR10 is annotated at the cell surface, where native CCR10 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CCR10 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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