Seroatlas · Human Serome Atlas

CCNP

Cyclin-P

Also known as: CCNP_HUMAN, CNTD2, FLJ13265

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H8S5
Gene: CCNP
Ensembl: ENSG00000105219
Chromosome: 19
Canonical length: 307 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in G1/S transition of mitotic cell cycle. Located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

307 residues, UniProt reviewed canonical sequence.

>Q9H8S5|CCNP
     1  MLVRGRDQGS GSRLGPIVRR WAPRPSPLQS LAASLDAEPS SAAVPDGFPA GPTVSPRRLA
    61  RPPGLEEALS ALGLQGEREY AGDIFAEVMV CRVLPLRALP RAVTPEMRAL VVDWLVQVHE
   121  YLGLAGDTLY LAVHLLDSYL SAGRVRLHRL QLLGVACLFV ACKMEECVLP EPAFLCLLSA
   181  DSFSRAELLR AERRILSRLD FRLHHPGPLL CLGLLAALAG SSPQVMLLAT YFLELSLLEA
   241  EAAGWEPGRR AAAALSLAHR LLDGAGSRLQ PELYRCSLGG GSVWGHRSFR DLPSWSFLRS
   301  RRMRDNY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.38
Highest tissue expression: 5.9 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 5.9 nTPM
kidney: 5.7 nTPM
liver: 3 nTPM
pituitary gland: 1.5 nTPM
thyroid gland: 0.8 nTPM
adipose tissue: 0.6 nTPM

Single-cell type

loop of henle epithelial cells: 37 nCPM
oocytes: 32 nCPM
tuft cells: 23 nCPM
fallopian tube ciliated cells: 15 nCPM
syncytiotrophoblasts: 14 nCPM
early spermatids: 12 nCPM

Immune cell

basophil: 4.5 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebellum: 7.4 nTPM
cerebral cortex: 1.9 nTPM
basal ganglia: 1.6 nTPM
hippocampal formation: 1.6 nTPM
pons: 1.6 nTPM
amygdala: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0
DepMap mean gene effect: -0.01
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

G1/S transition of mitotic cell cycle

Molecular functions

cyclin-dependent protein serine/threonine kinase regulator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Nucleus

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNP as an antibody target. Whether an autoantibody or antibody against CCNP could matter depends on whether native CCNP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCNP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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