CCNO

Protein identityUniProt · HPA

UniProt accession

P22674

Gene

CCNO

Ensembl

ENSG00000152669

Chromosome

5

Canonical length

350 aa

Protein class

Disease related genes, Human disease related genes, Plasma proteins, Predicted intracellular proteins

Subcellular location

Nucleoli,Centriolar satellite

OverviewNCBI Gene

This gene encodes a member of the cyclin protein family, and the encoded protein is involved in regulation of the cell cycle. Disruption of this gene is associated with primary ciliary dyskinesia-19. Alternative splicing results in multiple transcript variants. This gene, which has a previous symbol of UNG2, was erroneously identified as a uracil DNA glycosylase in PubMed ID: 2001396. A later publication, PubMed ID: 8419333, identified this gene's product as a cyclin protein family member. The UNG2 symbol is also used as a specific protein isoform name for the UNG gene (GeneID 7374), so confusion exists in the scientific literature and in some databases for these two genes. [provided by RefSeq, Jul 2014]

Canonical amino-acid sequenceUniProt

350 residues, UniProt reviewed canonical sequence.

>P22674|CCNO
     1  MVTPCPTSPS SPAARAGRRD NDQNLRAPVK KSRRPRLRRK QPLHPLNPCP LPGDSGICDL
    61  FESPSSGSDG AESPSAARGG SPLPGPAQPV AQLDLQTFRD YGQSCYAFRK AQESHFHPRE
   121  ALARQPQVTA ESRCKLLSWL IPVHRQFGLS FESLCLTVNT LDRFLTTTPV AADCFQLLGV
   181  TSLLIACKQV EVHPPRVKQL LALCCGAFSR QQLCNLECIV LHKLHFTLGA PTISFFLEHF
   241  THARVEAGQA EASEALEAQA LARGVAELSL ADYAFTSYSP SLLAICCLAL ADRMLRVSRP
   301  VDLRLGDHPE AALEDCMGKL QLLVAINSTS LTHMLPVQIC EKCSLPPSSK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNO can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.37

Highest tissue expression

13 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCNO.

Disease | AllUniProt

Conditions CCNO is implicated in, by any mechanism.

• Ciliary dyskinesia, primary, 29 (CILD29) MIM:615872

Disease | GeneticClinVar

39 pathogenic / likely-pathogenic of 271 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Primary ciliary dyskinesia
• Primary ciliary dyskinesia 29

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.17

gnomAD pLI

0

gnomAD missense Z

-0.14

DepMap mean gene effect

0

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell division
• cilium assembly
• G1/S transition of mitotic cell cycle
• mitotic cell cycle
• multi-ciliated epithelial cell differentiation
• seminiferous tubule development
• single fertilization
• spermatogenesis

Molecular functions

• cyclin-dependent protein serine/threonine kinase regulator activity

Cellular components

• centriolar satellite
• cyclin-dependent protein kinase holoenzyme complex
• cytoplasm
• microtubule organizing center
• nucleolus
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Cyclin, C-terminal domain
• Cyclin, N-terminal
• Cyclin-like domain
• Cyclin-like superfamily
• Cyclin
• Cyclin, N-terminal domain
• Cyclin, C-terminal domain

KeywordsUniProt

• Cell cycle
• Cell division
• Ciliopathy
• Cilium biogenesis/degradation
• Cyclin
• Cytoplasm
• Nucleus
• Phosphoprotein
• Primary ciliary dyskinesia

InteractionsUniProt · HPA

Protein binding partners of CCNO in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CDKN1A