Seroatlas · Human Serome Atlas

CCNJ

Cyclin-J

Also known as: bA690P14.1, CCNJ_HUMAN, FLJ10895

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5T5M9
Gene: CCNJ
Ensembl: ENSG00000107443
Chromosome: 10
Canonical length: 372 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in G1/S transition of mitotic cell cycle. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

372 residues, UniProt reviewed canonical sequence.

>Q5T5M9|CCNJ
     1  MELEGQWWRG QLAADIHQAL RYKELKLPSY KGQSPQLSLR RYFADLIAIV SNRFTLCPSA
    61  RHLAVYLLDL FMDRYDISIQ QLHLVALSCL LLASKFEEKE DSVPKLEQLN SLGCMTNMNL
   121  VLTKQNLLHM ELLLLETFQW NLCLPTAAHF IEYYLSEAVH ETDLHDGWPM ICLEKTKLYM
   181  AKYADYFLEV SLQVAAACVA SSRIILRLSP TWPTRLHRLT AYSWDFLVQC IERLLIAHDN
   241  DVKEANKQRG QAGPQSAQLS VFQTASQPSR PVHFQQPQYL HQTHQTSLQY RHPTSEQPSC
   301  QQIVSTTHTS SYTLQTCPAG FQTSVQGLGH MQTGVGMSLA IPVEVKPCLS VSYNRSYQIN
   361  EHYPCITPCF ER

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNJ can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.41
Highest tissue expression: 11 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 11 nTPM
parathyroid gland: 4.7 nTPM
spleen: 4.7 nTPM
lymph node: 4.5 nTPM
adrenal gland: 4.2 nTPM
duodenum: 4.1 nTPM

Single-cell type

cardiomyocytes: 79 nCPM
megakaryocytes: 43 nCPM
epicardial cells: 34 nCPM
adipocytes: 21 nCPM
early primary spermatocytes: 16 nCPM
erythrocyte progenitors: 16 nCPM

Immune cell

myeloid DC: 2.9 nTPM
classical monocyte: 1.7 nTPM
intermediate monocyte: 1.4 nTPM
non-classical monocyte: 1.3 nTPM
MAIT T-cell: 1.2 nTPM
naive CD4 T-cell: 1.1 nTPM

Brain region

cerebellum: 7.5 nTPM
medulla oblongata: 7 nTPM
white matter: 6.9 nTPM
hypothalamus: 6.6 nTPM
pons: 6.5 nTPM
thalamus: 6.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.17
gnomAD pLI: 1
gnomAD missense Z: 1.6
DepMap mean gene effect: -0.06
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

G1/S transition of mitotic cell cycle

Molecular functions

cyclin-dependent protein serine/threonine kinase regulator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Cyclin

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNJ as an antibody target. Whether an autoantibody or antibody against CCNJ could matter depends on whether native CCNJ is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNJ is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCNJ as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...