Seroatlas · Human Serome Atlas

CCNI2

Cyclin-I2

Also known as: CCNI2_HUMAN, FLJ16793

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6ZMN8
Gene: CCNI2
Ensembl: ENSG00000205089
Chromosome: 5
Canonical length: 369 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Golgi apparatus,Cytosol

OverviewNCBI Gene

Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Predicted to be involved in G1/S transition of mitotic cell cycle. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

369 residues, UniProt reviewed canonical sequence.

>Q6ZMN8|CCNI2
     1  MASGAQLPPQ PSSSEVSAVQ SPGGRPGAGL EETALGVPLP PSPGEAPLPR SNRSRCPGTR
    61  QPGAASLHAA SAAVPVRPRR GTAPAGKTAD AVPAAAPEQA PRPAPQSRKP RNLEGDLDER
   121  RLLCHLQLAQ DREARLWRGG KPQDEICDAF EEVVLWLLRL QNTFYFSQST FNLALTIFGR
   181  LLISVKVKEK YLHCATITSL RLAAKVNEEE EFIPQVKDFT KHYGSDYSPN ELLRMELAIL
   241  DRLHWDLYIG TPLDFLTIFH ALVVLSWPHV LELLPQRNPS LHVASLTRQL QHCMAGHQLL
   301  QFKGSTLALV IITLELERLM PGWCAPISDL LKKAQVGDMQ YSCCKELVMQ QLRSLQSSSC
   361  TDNFVSPAN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNI2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 4.6 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 4.6 nTPM
spinal cord: 4.1 nTPM
duodenum: 3.4 nTPM
rectum: 2.6 nTPM
colon: 2.5 nTPM
salivary gland: 2.5 nTPM

Single-cell type

oocytes: 69 nCPM
epididymal clear cells: 45 nCPM
renal collecting duct intercalated cells: 21 nCPM
plasma cells: 13 nCPM
cardiomyocytes: 11 nCPM
colonocytes: 9.6 nCPM

Immune cell

T-reg: 0.8 nTPM
MAIT T-cell: 0.6 nTPM
memory CD4 T-cell: 0.5 nTPM
memory CD8 T-cell: 0.5 nTPM
naive CD4 T-cell: 0.5 nTPM
basophil: 0.2 nTPM

Brain region

white matter: 12 nTPM
medulla oblongata: 8.6 nTPM
basal ganglia: 7.5 nTPM
pons: 7.2 nTPM
thalamus: 6.9 nTPM
cerebral cortex: 6.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.61
gnomAD pLI: 0
gnomAD missense Z: 1.19
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

G1/S transition of mitotic cell cycle

Molecular functions

cyclin-dependent protein serine/threonine kinase regulator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Cyclin

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNI2 as an antibody target. Whether an autoantibody or antibody against CCNI2 could matter depends on whether native CCNI2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNI2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCNI2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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