Seroatlas · Human Serome Atlas

CCNG2

Cyclin-G2

Also known as: CCNG2_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q16589
Gene: CCNG2
Ensembl: ENSG00000138764
Chromosome: 4
Canonical length: 344 aa
Protein class: Cancer-related genes, Predicted intracellular proteins
Subcellular location: Nucleoplasm,Cytosol

OverviewNCBI Gene

The eukaryotic cell cycle is governed by cyclin-dependent protein kinases (CDKs) whose activities are regulated by cyclins and CDK inhibitors. The 8 species of cyclins reported in mammals, cyclins A through H, share a conserved amino acid sequence of about 90 residues called the cyclin box. The amino acid sequence of cyclin G is well conserved among mammals. The nucleotide sequence of cyclin G1 and cyclin G2 are 53% identical. Unlike cyclin G1, cyclin G2 contains a C-terminal PEST protein destabilization motif, suggesting that cyclin G2 expression is tightly regulated through the cell cycle. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>Q16589|CCNG2
     1  MKDLGAEHLA GHEGVQLLGL LNVYLEQEER FQPREKGLSL IEATPENDNT LCPGLRNAKV
    61  EDLRSLANFF GSCTETFVLA VNILDRFLAL MKVKPKHLSC IGVCSFLLAA RIVEEDCNIP
   121  STHDVIRISQ CKCTASDIKR MEKIISEKLH YELEATTALN FLHLYHTIIL CHTSERKEIL
   181  SLDKLEAQLK ACNCRLIFSK AKPSVLALCL LNLEVETLKS VELLEILLLV KKHSKINDTE
   241  FFYWRELVSK CLAEYSSPEC CKPDLKKLVW IVSRRTAQNL HNSYYSVPEL PTIPEGGCFD
   301  ESESEDSCED MSCGEESLSS SPPSDQECTF FFNFKVAQTL CFPS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCNG2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.35
Highest tissue expression: 128 nTPM

Expression across tissuesHPA

Tissue

esophagus: 128 nTPM
bone marrow: 83 nTPM
cerebellum: 77 nTPM
breast: 76 nTPM
retina: 75 nTPM
prostate: 73 nTPM

Single-cell type

esophageal apical cells: 1,326 nCPM
neutrophils: 247 nCPM
breast hormone-responsive cells: 159 nCPM
extravillous trophoblasts: 146 nCPM
breast lactating cells: 143 nCPM
endometrial luminal cells: 142 nCPM

Immune cell

eosinophil: 21 nTPM
basophil: 15 nTPM
neutrophil: 8 nTPM
naive B-cell: 6.3 nTPM
T-reg: 6.1 nTPM
memory B-cell: 3.2 nTPM

Brain region

cerebellum: 130 nTPM
cerebral cortex: 40 nTPM
white matter: 36 nTPM
basal ganglia: 34 nTPM
amygdala: 29 nTPM
thalamus: 29 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.76
gnomAD pLI: 0.01
gnomAD missense Z: 0.67
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

cyclin-dependent protein serine/threonine kinase regulator activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCNG2 as an antibody target. Whether an autoantibody or antibody against CCNG2 could matter depends on whether native CCNG2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCNG2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCNG2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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