Seroatlas · Human Serome Atlas

CCL8

C-C motif chemokine 8

Also known as: CCL8_HUMAN, HC14, MCP-2, SCYA8

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P80075
Gene: CCL8
Ensembl: ENSG00000108700
Chromosome: 17
Canonical length: 99 aa
Protein class: Cancer-related genes, Predicted secreted proteins
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

This antimicrobial gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of N-terminal cysteine residues of the mature peptide. This chemokine is a member of the CC subfamily which is characterized by two adjacent cysteine residues. This cytokine displays chemotactic activity for monocytes, lymphocytes, basophils and eosinophils. By recruiting leukocytes to sites of inflammation this cytokine may contribute to tumor-associated leukocyte infiltration and to the antiviral state against HIV infection. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

99 residues, UniProt reviewed canonical sequence.

>P80075|CCL8
     1  MKVSAALLCL LLMAATFSPQ GLAQPDSVSI PITCCFNVIN RKIPIQRLES YTRITNIQCP
    61  KEAVIFKTKR GKEVCADPKE RWVRDSMKHL DQIFQNLKP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

colon: 17 nTPM
adipose tissue: 16 nTPM
small intestine: 16 nTPM
rectum: 15 nTPM
duodenum: 13 nTPM
urinary bladder: 13 nTPM

Single-cell type

pericytes: 113 nCPM
vascular smooth muscle cells: 106 nCPM
macrophages: 49 nCPM
decidual stromal cells: 15 nCPM
late primary spermatocytes: 13 nCPM
fallopian secretory cells: 12 nCPM

Immune cell

classical monocyte: 3.4 nTPM
memory B-cell: 0.6 nTPM
total PBMC: 0.5 nTPM
intermediate monocyte: 0.1 nTPM
myeloid DC: 0.1 nTPM
basophil: 0 nTPM

Brain region

spinal cord: 2.9 nTPM
thalamus: 1.6 nTPM
medulla oblongata: 0.5 nTPM
pons: 0.5 nTPM
choroid plexus: 0.4 nTPM
white matter: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0.04
gnomAD missense Z: 0.13
DepMap mean gene effect: 0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL8 as an antibody target. Whether an autoantibody or antibody against CCL8 could matter depends on whether native CCL8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL8 is annotated as secreted, so native CCL8 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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