Seroatlas · Human Serome Atlas

CCL4L1

C-C motif chemokine 4-like

Also known as: CC4L_HUMAN, CCL4L2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q8NHW4
Gene: CCL4L1
Ensembl: ENSG00000276070
Chromosome: 17
Canonical length: 92 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this family member is similar to the chemokine (C-C motif) ligand 4 product, which inhibits HIV entry by binding to the cellular receptor CCR5. The copy number of this gene varies among individuals, where most individuals have one to five copies. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

92 residues, UniProt reviewed canonical sequence.

>Q8NHW4|CCL4L1
     1  MKLCVTVLSL LVLVAAFCSL ALSAPMGSDP PTACCFSYTA RKLPRNFVVD YYETSSLCSQ
    61  PAVVFQTKRG KQVCADPSES WVQEYVYDLE LN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL4L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 30 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 30 nTPM
spleen: 19 nTPM
lung: 13 nTPM
liver: 7.1 nTPM
gallbladder: 6.3 nTPM
adipose tissue: 5.3 nTPM

Single-cell type

nk-cells: 39 nCPM
macrophages: 31 nCPM
t-cells: 25 nCPM
neutrophils: 23 nCPM
hofbauer cells: 22 nCPM
monocytes: 16 nCPM

Immune cell

eosinophil: 122 nTPM
neutrophil: 18 nTPM
gdT-cell: 15 nTPM
memory CD8 T-cell: 8.9 nTPM
naive CD8 T-cell: 8.4 nTPM
total PBMC: 5.5 nTPM

Brain region

cerebral cortex: 0.8 nTPM
cerebellum: 0.6 nTPM
choroid plexus: 0.4 nTPM
white matter: 0.3 nTPM
amygdala: 0.2 nTPM
hippocampal formation: 0.2 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCL4L1.

Disease | ImmuneIEDB

Conditions an epitope on CCL4L1 was assayed in.

berylliosis T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0.34
gnomAD missense Z: 0.4

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCL4L1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

CCR5

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL4L1 as an antibody target. Whether an autoantibody or antibody against CCL4L1 could matter depends on whether native CCL4L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL4L1 is annotated as secreted, so native CCL4L1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL4L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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