Seroatlas · Human Serome Atlas

CCL4

C-C motif chemokine 4

Also known as: Act-2, AT744.1, CCL4_HUMAN, LAG1, MIP-1-beta, SCYA4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P13236
Gene: CCL4
Ensembl: ENSG00000275302
Chromosome: 17
Canonical length: 92 aa
Protein class: Cancer-related genes, Predicted secreted proteins
Secretome location: Secreted to blood
Quaternary structure: Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a mitogen-inducible monokine and is one of the major HIV-suppressive factors produced by CD8+ T-cells. The encoded protein is secreted and has chemokinetic and inflammatory functions. [provided by RefSeq, Dec 2012]

Canonical amino-acid sequenceUniProt

92 residues, UniProt reviewed canonical sequence.

>P13236|CCL4
     1  MKLCVTVLSL LMLVAAFCSP ALSAPMGSDP PTACCFSYTA RKLPRNFVVD YYETSSLCSQ
    61  PAVVFQTKRS KQVCADPSES WVQEYVYDLE LN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 182 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 182 nTPM
liver: 79 nTPM
spleen: 78 nTPM
urinary bladder: 52 nTPM
lung: 44 nTPM
gallbladder: 42 nTPM

Single-cell type

nk-cells: 414 nCPM
t-cells: 186 nCPM
macrophages: 101 nCPM
monocytes: 87 nCPM
hofbauer cells: 85 nCPM
neutrophils: 62 nCPM

Immune cell

gdT-cell: 416 nTPM
memory CD8 T-cell: 241 nTPM
naive CD8 T-cell: 182 nTPM
total PBMC: 139 nTPM
eosinophil: 136 nTPM
MAIT T-cell: 102 nTPM

Brain region

choroid plexus: 5.3 nTPM
cerebellum: 3.9 nTPM
white matter: 3.8 nTPM
medulla oblongata: 3.5 nTPM
cerebral cortex: 3.4 nTPM
pons: 2.7 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCL4.

Disease | ImmuneIEDB

Conditions an epitope on CCL4 was assayed in.

berylliosis T cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.37
gnomAD pLI: 0.24
gnomAD missense Z: -0.64
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL4 as an antibody target. Whether an autoantibody or antibody against CCL4 could matter depends on whether native CCL4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL4 is annotated as secreted, so native CCL4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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