Seroatlas · Human Serome Atlas

CCL3L1

C-C motif chemokine 3-like 1

Also known as: CCL3L3, CL3L1_HUMAN, D17S1718, G0S19-2, LD78BETA, MGC12815, SCYA3L, SCYA3L1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P16619
Gene
CCL3L1
Ensembl
ENSG00000276085
Chromosome
17
Canonical length
93 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This gene is one of several cytokine genes that are clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins that function in inflammatory and immunoregulatory processes. The protein encoded by this gene binds to several chemokine receptors, including chemokine binding protein 2 and chemokine (C-C motif) receptor 5 (CCR5). CCR5 is a co-receptor for HIV, and binding of this protein to CCR5 inhibits HIV entry. The copy number of this gene varies among individuals, where most individuals have one to six copies, and a minority of individuals have zero or more than six copies. There are conflicting reports about copy number variation of this gene and its correlation to disease susceptibility. This record represents one of two copies that are present on the ALT_REF_LOCI_2 alternate haplotype of the GRCh38 human reference genome assembly. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

93 residues, UniProt reviewed canonical sequence.

>P16619|CCL3L1
     1  MQVSTAALAV LLCTMALCNQ VLSAPLAADT PTACCFSYTS RQIPQNFIAD YFETSSQCSK
    61  PSVIFLTKRG RQVCADPSEE WVQKYVSDLE LSA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL3L1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
11 nTPM

Expression across tissuesHPA

Tissue

  • bone marrow: 11 nTPM
  • lung: 5.1 nTPM
  • spleen: 3.9 nTPM
  • blood vessel: 2 nTPM
  • spinal cord: 2 nTPM
  • midbrain: 1.7 nTPM

Single-cell type

  • microglia: 10 nCPM
  • macrophages: 8.8 nCPM
  • monocytes: 6.7 nCPM
  • neutrophils: 5.3 nCPM
  • nk-cells: 3.9 nCPM
  • cdc: 3.8 nCPM

Immune cell

  • eosinophil: 4.2 nTPM
  • neutrophil: 1.2 nTPM
  • gdT-cell: 0.4 nTPM
  • memory CD8 T-cell: 0.3 nTPM
  • MAIT T-cell: 0.2 nTPM
  • basophil: 0.1 nTPM

Brain region

  • cerebral cortex: 0.2 nTPM
  • thalamus: 0.2 nTPM
  • medulla oblongata: 0.1 nTPM
  • pons: 0.1 nTPM
  • white matter: 0.1 nTPM
  • amygdala: 0 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.83
gnomAD pLI
0.12
gnomAD missense Z
0.27
DepMap mean gene effect
-0.03
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL3L1 as an antibody target. Whether an autoantibody or antibody against CCL3L1 could matter depends on whether native CCL3L1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL3L1 is annotated as secreted, so native CCL3L1 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL3L1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCL3L1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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