Seroatlas · Human Serome Atlas

CCL28

C-C motif chemokine 28

Also known as: CCK1, CCL28_HUMAN, MEC, SCYA28

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9NRJ3
Gene
CCL28
Ensembl
ENSG00000151882
Chromosome
5
Canonical length
127 aa
Protein class
Predicted intracellular proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

127 residues, UniProt reviewed canonical sequence.

>Q9NRJ3|CCL28
     1  MQQRGLAIVA LAVCAALHAS EAILPIASSC CTEVSHHISR RLLERVNMCR IQRADGDCDL
    61  AAVILHVKRR RICVSPHNHT VKQWMKVQAA KKNGKGNVCH RKKHHGKRNS NRAHQGKHET
   121  YGHKTPY

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL28 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
283 nTPM

Expression across tissuesHPA

Tissue

  • salivary gland: 283 nTPM
  • breast: 56 nTPM
  • colon: 29 nTPM
  • rectum: 26 nTPM
  • duodenum: 23 nTPM
  • thyroid gland: 21 nTPM

Single-cell type

  • lacrimal acinar cells: 1,366 nCPM
  • salivary acinar cells: 1,223 nCPM
  • breast lactating cells: 567 nCPM
  • breast secretory cells: 534 nCPM
  • salivary myoepithelial cells: 324 nCPM
  • salivary duct cells: 320 nCPM

Immune cell

  • T-reg: 6 nTPM
  • naive B-cell: 4.3 nTPM
  • naive CD4 T-cell: 4.3 nTPM
  • basophil: 4 nTPM
  • memory B-cell: 4 nTPM
  • memory CD4 T-cell: 3.7 nTPM

Brain region

  • midbrain: 7.3 nTPM
  • white matter: 6.5 nTPM
  • choroid plexus: 5.7 nTPM
  • medulla oblongata: 5.7 nTPM
  • cerebral cortex: 5.6 nTPM
  • pons: 5.3 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCL28.

Disease | ImmuneIEDB

Conditions an epitope on CCL28 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.65
gnomAD pLI
0.05
gnomAD missense Z
0.45
DepMap mean gene effect
-0.04
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL28 as an antibody target. Whether an autoantibody or antibody against CCL28 could matter depends on whether native CCL28 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL28 is annotated as secreted, so native CCL28 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL28 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCL28. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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