Seroatlas · Human Serome Atlas

CCL26

C-C motif chemokine 26

Also known as: CCL26_HUMAN, eotaxin-3, IMAC, MIP-4a, MIP-4alpha, SCYA26, TSC-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y258
Gene: CCL26
Ensembl: ENSG00000006606
Chromosome: 7
Canonical length: 94 aa
Protein class: Human disease related genes, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene is one of two Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 7. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for normal peripheral blood eosinophils and basophils. This protein also has antimicrobial activity, displaying an antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa. The product of this gene is one of three related chemokines that specifically activate chemokine receptor CCR3. This chemokine may contribute to the eosinophil accumulation in atopic diseases. [provided by RefSeq, Jul 2020]

Canonical amino-acid sequenceUniProt

94 residues, UniProt reviewed canonical sequence.

>Q9Y258|CCL26
     1  MMGLSLASAV LLASLLSLHL GTATRGSDIS KTCCFQYSHK PLPWTWVRSY EFTSNSCSQR
    61  AVIFTTKRGK KVCTHPRKKW VQKYISLLKT PKQL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL26 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 46 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 46 nTPM
ovary: 22 nTPM
pituitary gland: 18 nTPM
rectum: 6.7 nTPM
vagina: 4.3 nTPM
heart muscle: 4.1 nTPM

Single-cell type

pericytes: 38 nCPM
ovarian stromal cells: 26 nCPM
gastric progenitor cells: 15 nCPM
hepatic stellate cells: 13 nCPM
fibroblasts: 12 nCPM
leydig cells: 11 nCPM

Immune cell

intermediate monocyte: 0.5 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

choroid plexus: 18 nTPM
thalamus: 1 nTPM
basal ganglia: 0.7 nTPM
spinal cord: 0.7 nTPM
medulla oblongata: 0.6 nTPM
cerebral cortex: 0.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.75
gnomAD pLI: 0.01
gnomAD missense Z: -0.2
DepMap mean gene effect: -0.14
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL26 as an antibody target. Whether an autoantibody or antibody against CCL26 could matter depends on whether native CCL26 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL26 is annotated as secreted, so native CCL26 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL26 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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