Seroatlas · Human Serome Atlas

CCL25

C-C motif chemokine 25

Also known as: CCL25_HUMAN, Ckb15, SCYA25, TECK

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15444
Gene: CCL25
Ensembl: ENSG00000131142
Chromosome: 19
Canonical length: 150 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for dendritic cells, thymocytes, and activated macrophages but is inactive on peripheral blood lymphocytes and neutrophils. The product of this gene binds to chemokine receptor CCR9. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

150 residues, UniProt reviewed canonical sequence.

>O15444|CCL25
     1  MNLWLLACLV AGFLGAWAPA VHTQGVFEDC CLAYHYPIGW AVLRRAWTYR IQEVSGSCNL
    61  PAAIFYLPKR HRKVCGNPKS REVQRAMKLL DARNKVFAKL HHNTQTFQAG PHAVKKLSSG
   121  NSKLSSSKFS NPISSSKRNV SLLISANSGL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL25 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 718 nTPM

Expression across tissuesHPA

Tissue

thymus: 718 nTPM
small intestine: 547 nTPM
duodenum: 482 nTPM
lymph node: 1.3 nTPM
colon: 1 nTPM
tonsil: 0.7 nTPM

Single-cell type

paneth cells: 874 nCPM
enterocytes: 661 nCPM
enteric transient amplifying cells: 388 nCPM
enteric stem cells: 329 nCPM
goblet cells: 47 nCPM
epididymal efferent duct ciliated cells: 8 nCPM

Immune cell

NK-cell: 3.5 nTPM
memory B-cell: 0.7 nTPM
naive CD4 T-cell: 0.1 nTPM
total PBMC: 0.1 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM

Brain region

cerebral cortex: 0.4 nTPM
hypothalamus: 0.4 nTPM
amygdala: 0.3 nTPM
basal ganglia: 0.3 nTPM
hippocampal formation: 0.3 nTPM
medulla oblongata: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.1
gnomAD pLI: 0.02
gnomAD missense Z: 0.98
DepMap mean gene effect: 0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL25 as an antibody target. Whether an autoantibody or antibody against CCL25 could matter depends on whether native CCL25 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL25 is annotated as secreted, so native CCL25 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL25 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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