Seroatlas · Human Serome Atlas

CCL24

C-C motif chemokine 24

Also known as: CCL24_HUMAN, Ckb-6, eotaxin-2, MPIF-2, MPIF2, SCYA24

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O00175
Gene: CCL24
Ensembl: ENSG00000106178
Chromosome: 7
Canonical length: 119 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity on resting T lymphocytes, a minimal activity on neutrophils, and is negative on monocytes and activated T lymphocytes. This protein also has antimicrobial activity, displaying an antibacterial effect on S. pneumoniae, S. aureus, Non-typeable H. influenzae, and P. aeruginosa. Finally, the protein is a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. [provided by RefSeq, Jul 2020]

Canonical amino-acid sequenceUniProt

119 residues, UniProt reviewed canonical sequence.

>O00175|CCL24
     1  MAGLMTIVTS LLFLGVCAHH IIPTGSVVIP SPCCMFFVSK RIPENRVVSY QLSSRSTCLK
    61  AGVIFTTKKG QQFCGDPKQE WVQRYMKNLD AKQKKASPRA RAVAVKGPVQ RYPGNQTTC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL24 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 77 nTPM

Expression across tissuesHPA

Tissue

spleen: 77 nTPM
rectum: 67 nTPM
small intestine: 59 nTPM
colon: 26 nTPM
duodenum: 22 nTPM
appendix: 15 nTPM

Single-cell type

paneth cells: 155 nCPM
kupffer cells: 110 nCPM
macrophages: 71 nCPM
goblet cells: 48 nCPM
cdc: 29 nCPM
early spermatids: 18 nCPM

Immune cell

basophil: 0.7 nTPM
intermediate monocyte: 0.7 nTPM
neutrophil: 0.5 nTPM
NK-cell: 0.3 nTPM
classical monocyte: 0.2 nTPM
naive B-cell: 0.2 nTPM

Brain region

white matter: 4.6 nTPM
cerebellum: 4.4 nTPM
thalamus: 3.8 nTPM
cerebral cortex: 3.4 nTPM
medulla oblongata: 3.4 nTPM
pons: 3.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.84
gnomAD pLI: 0.01
gnomAD missense Z: 0.69
DepMap mean gene effect: -0.01
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

extracellular space

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL24 as an antibody target. Whether an autoantibody or antibody against CCL24 could matter depends on whether native CCL24 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL24 is annotated as secreted, so native CCL24 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL24 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...