Seroatlas · Human Serome Atlas

CCL22

C-C motif chemokine 22

Also known as: A-152E5.1, ABCD-1, CCL22_HUMAN, DC/B-CK, MDC, MGC34554, SCYA22, STCP-1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
O00626
Gene
CCL22
Ensembl
ENSG00000102962
Chromosome
16
Canonical length
93 aa
Protein class
Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for monocytes, dendritic cells, natural killer cells and for chronically activated T lymphocytes. It also displays a mild activity for primary activated T lymphocytes and has no chemoattractant activity for neutrophils, eosinophils and resting T lymphocytes. The product of this gene binds to chemokine receptor CCR4. This chemokine may play a role in the trafficking of activated T lymphocytes to inflammatory sites and other aspects of activated T lymphocyte physiology. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

93 residues, UniProt reviewed canonical sequence.

>O00626|CCL22
     1  MDRLQTALLV VLVLLAVALQ ATEAGPYGAN MEDSVCCRDY VRYRLPLRVV KHFYWTSDSC
    61  PRPGVVLLTF RDKEICADPR VPWVKMILNK LSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL22 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
14 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 14 nTPM
  • tonsil: 14 nTPM
  • appendix: 13 nTPM
  • skin: 6.2 nTPM
  • lymph node: 5.5 nTPM
  • rectum: 5.1 nTPM

Single-cell type

  • cdc: 160 nCPM
  • macrophages: 15 nCPM
  • suprabasal keratinocytes: 4.1 nCPM
  • monocytes: 3.8 nCPM
  • breast secretory cells: 2.7 nCPM
  • foveolar cells: 2.5 nCPM

Immune cell

  • basophil: 1.2 nTPM
  • neutrophil: 1.1 nTPM
  • memory B-cell: 1 nTPM
  • myeloid DC: 0.9 nTPM
  • naive B-cell: 0.4 nTPM
  • NK-cell: 0.3 nTPM

Brain region

  • cerebellum: 4.5 nTPM
  • white matter: 4.4 nTPM
  • choroid plexus: 3.9 nTPM
  • pons: 3.7 nTPM
  • basal ganglia: 3.6 nTPM
  • cerebral cortex: 3.6 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCL22.

Disease | ImmuneIEDB

Conditions an epitope on CCL22 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.8
gnomAD pLI
0.01
gnomAD missense Z
0.45
DepMap mean gene effect
0.02
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL22 as an antibody target. Whether an autoantibody or antibody against CCL22 could matter depends on whether native CCL22 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL22 is annotated as secreted, so native CCL22 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL22 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCL22. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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