Seroatlas · Human Serome Atlas

CCL20

C-C motif chemokine 20

Also known as: CCL20_HUMAN, CKb4, exodus-1, LARC, MIP-3a, SCYA20, ST38

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P78556
Gene: CCL20
Ensembl: ENSG00000115009
Chromosome: 2
Canonical length: 96 aa
Protein class: Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The protein encoded by this gene displays chemotactic activity for lymphocytes and can repress proliferation of myeloid progenitors. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

96 residues, UniProt reviewed canonical sequence.

>P78556|CCL20
     1  MCCTKSLLLA ALMSVLLLHL CGESEAASNF DCCLGYTDRI LHPKFIVGFT RQLANEGCDI
    61  NAIIFHTKKK LSVCANPKQT WVKYIVRLLS KKVKNM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL20 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.44
Highest tissue expression: 179 nTPM

Expression across tissuesHPA

Tissue

urinary bladder: 179 nTPM
tonsil: 155 nTPM
gallbladder: 153 nTPM
lung: 40 nTPM
appendix: 30 nTPM
rectum: 25 nTPM

Single-cell type

monocytes: 884 nCPM
endometrial glandular cells: 784 nCPM
esophageal apical cells: 722 nCPM
esophageal suprabasal cells: 648 nCPM
neutrophils: 593 nCPM
gastric progenitor cells: 473 nCPM

Immune cell

MAIT T-cell: 2.7 nTPM
memory CD4 T-cell: 1.1 nTPM
memory CD8 T-cell: 0.6 nTPM
T-reg: 0.5 nTPM
plasmacytoid DC: 0.3 nTPM
naive CD4 T-cell: 0.2 nTPM

Brain region

cerebellum: 10 nTPM
white matter: 9.6 nTPM
thalamus: 8.4 nTPM
cerebral cortex: 8.3 nTPM
basal ganglia: 7.4 nTPM
pons: 7.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.88
gnomAD pLI: 0
gnomAD missense Z: 0.59
DepMap mean gene effect: 0.1
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL20 as an antibody target. Whether an autoantibody or antibody against CCL20 could matter depends on whether native CCL20 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL20 is annotated as secreted, so native CCL20 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL20 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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