Seroatlas · Human Serome Atlas

CCL18

C-C motif chemokine 18

Also known as: AMAC-1, CCL18_HUMAN, CKb7, DC-CK1, DCCK1, MIP-4, PARC, SCYA18

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P55774
Gene
CCL18
Ensembl
ENSG00000275385
Chromosome
17
Canonical length
89 aa
Protein class
Cancer-related genes, Plasma proteins, Predicted secreted proteins
Secretome location
Secreted to blood

OverviewNCBI Gene

This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for naive T cells, CD4+ and CD8+ T cells and nonactivated lymphocytes, but not for monocytes or granulocytes. This chemokine attracts naive T lymphocytes toward dendritic cells and activated macrophages in lymph nodes. It may play a role in both humoral and cell-mediated immunity responses. [provided by RefSeq, Sep 2014]

Canonical amino-acid sequenceUniProt

89 residues, UniProt reviewed canonical sequence.

>P55774|CCL18
     1  MKGLAAALLV LVCTMALCSC AQVGTNKELC CLVYTSWQIP QKFIVDYSET SPQCPKPGVI
    61  LLTKRGRQIC ADPNKKWVQK YISDLKLNA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Secreted
Secreted
Yes
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.44
Highest tissue expression
47 nTPM

Expression across tissuesHPA

Tissue

  • lung: 47 nTPM
  • adipose tissue: 9 nTPM
  • small intestine: 8.8 nTPM
  • blood vessel: 8.2 nTPM
  • lymph node: 6.8 nTPM
  • thymus: 5.7 nTPM

Single-cell type

  • early spermatids: 9.4 nCPM
  • late spermatids: 4.7 nCPM
  • macrophages: 4 nCPM
  • innate lymphoid cells: 0.7 nCPM
  • cdc: 0.6 nCPM
  • choroid plexus epithelial cells: 0.4 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 0.3 nTPM
  • white matter: 0.1 nTPM
  • amygdala: 0 nTPM
  • basal ganglia: 0 nTPM
  • cerebellum: 0 nTPM
  • cerebral cortex: 0 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CCL18.

Disease | ImmuneIEDB

Conditions an epitope on CCL18 was assayed in.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.78
gnomAD pLI
0.01
gnomAD missense Z
0.17
DepMap mean gene effect
-0.03
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL18 as an antibody target. Whether an autoantibody or antibody against CCL18 could matter depends on whether native CCL18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL18 is annotated as secreted, so native CCL18 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Source-annotated serology context

The source annotations explicitly mention antibody, autoantibody, autoantigen, or autoimmune context. This is biological context, not study-specific reactivity.

  • It may play a role in both humoral and cell-mediated immunity responses.

Canonical record: https://seroatlas.com/gene/CCL18. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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