CCL17
C-C motif chemokine 17
Also known as: ABCD-2, CCL17_HUMAN, SCYA17, TARC
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q92583
- Gene
- CCL17
- Ensembl
- ENSG00000102970
- Chromosome
- 16
- Canonical length
- 94 aa
- Protein class
- Predicted secreted proteins
- Secretome location
- Secreted to blood
OverviewNCBI Gene
This antimicrobial gene is one of several Cys-Cys (CC) cytokine genes clustered on the q arm of chromosome 16. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for T lymphocytes, but not monocytes or granulocytes. The product of this gene binds to chemokine receptors CCR4 and CCR8. This chemokine plays important roles in T cell development in thymus as well as in trafficking and activation of mature T cells. [provided by RefSeq, Sep 2014]
Canonical amino-acid sequenceUniProt
94 residues, UniProt reviewed canonical sequence.
>Q92583|CCL17
1 MAPLKMLALV TLLLGASLQH IHAARGTNVG RECCLEYFKG AIPLRKLKTW YQTSEDCSRD
61 AIVFVTVQGR AICSDPNNKR VKNAVKYLQS LERSLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CCL17 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.45
- Highest tissue expression
- 20 nTPM
Expression across tissuesHPA
Tissue
- thymus: 20 nTPM
- lymph node: 7.9 nTPM
- appendix: 7.8 nTPM
- tonsil: 5.3 nTPM
- lung: 4.4 nTPM
- small intestine: 3.4 nTPM
Single-cell type
- cdc: 124 nCPM
- esophageal apical cells: 29 nCPM
- macrophages: 17 nCPM
- monocytes: 12 nCPM
- esophageal suprabasal cells: 6.2 nCPM
- salivary duct cells: 4.5 nCPM
Immune cell
- memory B-cell: 0.2 nTPM
- myeloid DC: 0.1 nTPM
- naive CD4 T-cell: 0.1 nTPM
- basophil: 0 nTPM
- classical monocyte: 0 nTPM
- eosinophil: 0 nTPM
Brain region
- cerebral cortex: 1 nTPM
- hippocampal formation: 0.5 nTPM
- thalamus: 0.5 nTPM
- white matter: 0.5 nTPM
- amygdala: 0.4 nTPM
- basal ganglia: 0.4 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.92
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.48
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CCL17 as an antibody target. Whether an autoantibody or antibody against CCL17 could matter depends on whether native CCL17 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CCL17 is annotated as secreted, so native CCL17 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label CCL17 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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