Seroatlas · Human Serome Atlas

CCL16

C-C motif chemokine 16

Also known as: CCL16_HUMAN, CKb12, HCC-4, LCC-1, LEC, LMC, Mtn-1, NCC-4, SCYA16, SCYL4

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O15467
Gene: CCL16
Ensembl: ENSG00000275152
Chromosome: 17
Canonical length: 120 aa
Protein class: Cancer-related genes, Plasma proteins, Predicted secreted proteins
Secretome location: Secreted to blood

OverviewNCBI Gene

This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for lymphocytes and monocytes but not for neutrophils. This cytokine also shows a potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells. The expression of this gene is upregulated by IL-10. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

120 residues, UniProt reviewed canonical sequence.

>O15467|CCL16
     1  MKVSEAALSL LVLILIITSA SRSQPKVPEW VNTPSTCCLK YYEKVLPRRL VVGYRKALNC
    61  HLPAIIFVTK RNREVCTNPN DDWVQEYIKD PNLPLLPTRN LSTVKIITAK NGQPQLLNSQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCL16 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.46
Highest tissue expression: 112 nTPM

Expression across tissuesHPA

Tissue

liver: 112 nTPM
spleen: 2.5 nTPM
adipose tissue: 0.7 nTPM
cervix: 0.7 nTPM
breast: 0.6 nTPM
endometrium: 0.5 nTPM

Single-cell type

hepatocytes: 72 nCPM
vascular endothelial cells: 0.5 nCPM
proximal tubule cells: 0.3 nCPM
lymphatic endothelial cells: 0.2 nCPM
papillary tip epithelial cells: 0.2 nCPM
astrocytes: 0.1 nCPM

Immune cell

basophil: 0.2 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 0.9 nTPM
choroid plexus: 0.2 nTPM
amygdala: 0.1 nTPM
midbrain: 0.1 nTPM
pons: 0.1 nTPM
thalamus: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.44
gnomAD pLI: 0.22
gnomAD missense Z: 0.12
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCL16 as an antibody target. Whether an autoantibody or antibody against CCL16 could matter depends on whether native CCL16 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCL16 is annotated as secreted, so native CCL16 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CCL16 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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